Local epidemiologic data on the etiologies of patients hospitalized with community-acquired pneumonia (CAP) is needed to develop guidelines for clinical practice. This study was conducted prospectively to determine the proportion of atypical bacterial pathogens in adults patients hospitalized with CAP in Korea between October 2001 and December 2002. Microbiological diagnosis was determined by s...

OBJECTIVE To investigate the current status of atypical pathogen associated infections in community-acquired pneumonia (CAP) in adults, and their clinical attributes. METHODS Clinical data, sputum specimens from acute phase, and paired sera from acute- and convalescent-phases of CAP in 153 adult patients were collected from May 2005 to May 2008 in multiple medical centers. Chlamydia pneumonia...

BACKGROUND The importance of Chlamydia pneumoniae as a cause of pneumonia has remained controversial. The clinical picture of C pneumoniae and Streptococcus pneumoniae in patients admitted to hospital with community-acquired pneumonia was compared during a C pneumoniae epidemic in Finland. METHODS Group I consisted of 24 patients in whom serological testing and bacterial culture indicated an ...

With interest we read the article of Saito et al. that describes a severe case of chlamydiosis in humans (3). However, according to us two major points need to be clarified. The taxonomy of chlamydiae has been illustrated in 1999 by Everett et al. (1), and such classification is accepted universally, as evidenced by a number of manuscripts published in recent years. Classification is based on d...

With interest we read the article of Saito et al. that describes a severe case of chlamydiosis in humans (3). However, according to us two major points need to be clarified. The taxonomy of chlamydiae has been illustrated in 1999 by Everett et al. (1), and such classification is accepted universally, as evidenced by a number of manuscripts published in recent years. Classification is based on d...

hclamydia pneumoniae is emerging as a frequent ause of respiratory disease in children as well as adults. C. pneumoniae infection in children presents a different set of problems regarding disease presentation and diagnosis compared to adults. Several studies of the role of C. pneumoniae in lower respiratory tract infection in pediatric populations have found evidence of infection in 0 to over ...

The in vitro and in vivo activities of AM-1155, a new quinolone, against Chlamydia spp. were investigated. The MIC of AM-1155 for 10 standard strains of different Chlamydia spp. and 25 wild-type strains of Chlamydia pneumoniae isolated in Japan, which were morphologically different from clinical isolates from the United States, ranged from 0.063 to 0.125 microg/ml. Its activity was almost the s...

Nasopharyngeal specimens for culture of Chlamydia pneumoniae were obtained from patients with community-acquired pneumonia enrolled in a randomized study comparing the novel ketolide antibiotic ABT-773 at a dose of 150 mg once a day to 150 mg twice a day, by mouth for 10 days. C. pneumoniae was eradicated from the nasopharynx of 10 of 10 (100%) microbiologically evaluable patients. MICs and MBC...

Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae-induced pneumonia in mice. Rip2(-/-) mice infected with C. pneumoniae exhibited impaired iNOS expression and NO production, and delayed neutrophil recruitment to the lungs. Levels of IL-6 and IFN-gamma levels as well as KC and MIP-2 levels in bronchoalveolar lavage fluid (BALF) were significantly...