Taxonomy The order chlamydiales has one family, chlamydiaceae, and one genus, chlamydia. Currently four species are recognized, Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci , and Chlamydia pecorum. To date, 19 different Chlamydia trachomatis serovars (41) and several Chlamydia psittaci serovars are known (6 avian (65), 9 mammalian (29)), but only one Chlamydia pneumoniae (40,...

We have shown that immunization with soluble recombinant chlamydial protease-like activity factor (rCPAF) and a T helper 1 type adjuvant can induce significantly enhanced bacterial clearance and protection against Chlamydia-induced pathological sequelae in the genital tract. In this study, we investigated the use of bone marrow derived dendritic cells (BMDCs) pulsed ex vivo with rCPAF + CpG in ...

Evidence has accumulated concerning the association of micro-organisms of the genus Chlamydia with Reiter's syndrome (RS). Isolations have been reported from the conjunctiva, genital tract, and synovial fluid or tissue, and antichlamydial complement-fixing (CF) antibodies have been demonstrated in the sera of patients (Schachter, Barnes, Jones, Engleman, and Meyer, 1966; Schachter, 1967; Kinsel...

Background: Chlamydia trachomatis(CT) is an obligate intracellular bacteria, requires living cells to replicate itself. CT infection can remain up to 4 years in the couple and affect their fertility. The relationship between CT and infertility is very important because most patients are asymptomatic and untreated. After infection with CT, NK activation signals begin through interactions of its ...

Since current studies indicate possible infection of human lymphocytes with Chlamydia (Chlamydophila) pneumoniae, establishment of an in vitro C. pneumoniae infection model using lymphocyte cell lines was demonstrated. Human lymphoid cell lines (Molt 4 [T-cell] and P3HR1 [B-cell]) were utilized for this purpose besides human monocyte cell line (THP-1) and human epithelial cell line (HEp-2), as ...

BACKGROUND CD14 has been postulated to play a role in chlamydial immunity and immunopathology. There is evidence to support this role in human infections but its function in a mouse model has not been investigated. METHODS Female CD14 gene knockout and C57BL/6J wild type mice were infected intravaginally with Chlamydia muridarum. The infection course was monitored by detection of viable chlam...

To simplify the diagnosis of chlamydial genital infection, we used a fluorescein-conjugated monoclonal antibody in immunofluorescence tests on smears prepared from urethral or cervical secretions obtained directly from patients. This direct test, requiring less than 30 minutes to perform, was based on the detection of extracellular chlamydial elementary bodies. A comparison of the direct test w...