The main purpose of this study is developed and drug loaded nanoparticles of azelastine hydrochloride, an antiallergic drug and optimization in terms of chemical properties, drug concentration, polymer concentration, cross‐linking agent and stirring time. Nanoparticles of azelastine hydrochloride were fabricated using chitosan and sodium alginate as polymers by ionotropic pregelation method. Ca...

Background: Chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

Photodynamic medicine is a novel approach for cancer detection and treatment via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX), and in cancer cells which serves as a fluorescent probe for tumor detection. In this study, folic acid was conjugated onto chitosan molecules via covalent bond for specific target,...

Iron oxide nanoparticles were synthesized and coated with silica by conventional coprecipitation method. Silica coated iron oxide nanoparticles were surface functionalized with chitosan. Silica coating and chitosan functionalization were confirmed by FTIR and TG-DTA analysis. XRD pattern revealed that the pure phase of Fe3O4 was retained even after coating. Particles of average size 12 nm were ...

Chitosan-coated magnetic nanoparticles (CMNP) were prepared in one-step by precipitation in a high-aqueous phase content reverse microemulsion in the presence of chitosan. The high-aqueous phase concentration led to productivities close to 0.49 g CMNP/100 g microemulsion; much higher than those characteristic of precipitation in reverse microemulsions for preparing magnetic nanoparticles. The o...

AIM To evaluate intraocular biodistribution of fluorescent nanoparticles composed of dexamethasone bound to chitosan after intravitreal administration in rabbit eyes. MATERIAL AND METHODS The chitosan and gelatin based nanoparticles were synthetized using a reverse emulsion-double crosslinking technique (ionic and covalent) and then dexamethasone was bound. Two units of 1% suspension of these...

Macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. Ferro-gels containing ferrous cations, ferric cations and chitosan were dropped into a sodium hydroxide solution through a syringe pump. In addition, a sodium hydroxide solution was employed for both gelation (chitosan) and co-precipitati...

background nowadays, removal of heavy metals from the environment is an important problem due to their toxicity. objectives in this study, a modified method was used to synthesize chitosan-coated magnetite nanoparticles (ccmn) to be used as a low cost and nontoxic adsorbent. ccmn was then employed to remove hg2+ from water solutions. materials and methods to remove the highest percentage of mer...

Silane modified iron (III) oxide (SiFe2O3) nanoparticles reinforced chitosan (CS) nanocomposite membranes were prepared by solcast transformation method. The iron (III) oxide nanoparticles and nanocomposite membranes were investigated by UV (Visible) spectroscopy, FT-IR spectroscopy, XRD, SEM and TEM. The size and shape of iron (III) oxide and Si-Fe2O3 nanoparticles were determined by XRD and T...