BACKGROUND Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal delivery of exendin-4. METHODS AND RESULTS Nanoparticles were prepared using a modified water-oil...

This paper provides an overview of how the surface properties of ferromagnetic nanoparticles dispersed in fluids is modified by natural and biocompatible polymers. Among common magnetic nanoparticles, magnetite (Fe3O4) and maghemite (g-Fe203) are popular candidates because of their biocompatibility. Natural polymeric coating materials are the most commonly used biocompatible magnetic nanopartic...

Abstract Chitosan has been widely used as an excipient in the pharmaceutical industries, due to its biodegradable, biocompatible, low toxicity, and mucoadhesive properties. nanoparticles have extensively investigated for delivery of drugs, herbal products, proteins or peptides genes. The particle size chitosan important effect on their properties application. Smaller can entrap higher concentra...

Objective(s): The purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (TMPC) which are made P.E.C method, for bucal drug delivery of insulin.Materials and Methods: First of all have to synthesize methylated pyridinyl chitosan and then for (TMPC) L-cysteine should be attached to methylated pyridinyl chitosan by the fo...

Due to the release of active pharmaceutical compounds in wastewater and their persistence environment, dangerous consequences can develop aquatic terrestrial organisms. Chitosan/Ag/TiO2 3D printed scaffolds, at different Ag nanoparticle concentrations (10, 100, 1000 ppm) are investigated here as promising materials for photocatalytic degradation under UV–Vis irradiation wastewater. As target dr...

The present study attempted synthesis of gold nanoparticle using chitosan from shrimp waste and evaluated the kinetics (AuNPs) formation. Two different forms (high molecular weight medium forms) were used for preparation AuNPs. formation nanoparticles was studied UV-VIS spectra obtained at time intervals during synthesis. typical spectrum non-aggregated spherical AuNPs 520 nm both maximum absor...

Abstract New system compromising of chitosan nanoparticles encapsulated pre-synthesized selenium in the presence 5-fluorouracil was successfully prepared and used for cancer antiproliferation. Selenium were synthesized using ascorbic acid as reducing agent under mild condition. Chitosan via ionic gelation technique sodium tri-polyphosphate. Characterization carried out FTIR, TEM, XRD, TGA dynam...

Highly amino-functionalized fluorescent carbon nanoparticles (CNPs) were fabricated by hydrothermal carbonization of chitosan at a mild temperature. They were applied to bioimaging of human lung adenocarcinoma A549 cells, showing low cytotoxicity and excellent biocompatibility.