In this study four quaternized derivatives of chitosan: trimethyl chitosan (TMC), dimethylethyl chitosan (DMEC), diethylmethyl chitosan (DEMC) and triethyl chitosan (TEC) with degree of substitution of approximately 50+/-5% were synthesized and their effect on the permeability of insulin across intestinal Caco-2 monolayers was studied and compared with chitosan both in free-soluble form and in ...

The main purpose of this study is developed and drug loaded nanoparticles of azelastine hydrochloride, an antiallergic drug and optimization in terms of chemical properties, drug concentration, polymer concentration, cross‐linking agent and stirring time. Nanoparticles of azelastine hydrochloride were fabricated using chitosan and sodium alginate as polymers by ionotropic pregelation method. Ca...

The present study was aimed to develop and evaluate nanoparticulate containing pioglitazone HCl as potential antidiabetic drug delivery system. The pioglitazone HCl -loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions at various concentrations. The nanoparticles were characterized by zeta potential analyzer; particle size analyzer and Fourier t...

Photodynamic medicine is a novel approach for cancer detection and treatment via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX), and in cancer cells which serves as a fluorescent probe for tumor detection. In this study, folic acid was conjugated onto chitosan molecules via covalent bond for specific target,...

conclusions diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac. objectives the aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. materials and methods chitosan (cs) nanoparticles contai...

Iron oxide nanoparticles were synthesized and coated with silica by conventional coprecipitation method. Silica coated iron oxide nanoparticles were surface functionalized with chitosan. Silica coating and chitosan functionalization were confirmed by FTIR and TG-DTA analysis. XRD pattern revealed that the pure phase of Fe3O4 was retained even after coating. Particles of average size 12 nm were ...

AIM To evaluate intraocular biodistribution of fluorescent nanoparticles composed of dexamethasone bound to chitosan after intravitreal administration in rabbit eyes. MATERIAL AND METHODS The chitosan and gelatin based nanoparticles were synthetized using a reverse emulsion-double crosslinking technique (ionic and covalent) and then dexamethasone was bound. Two units of 1% suspension of these...

Macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. Ferro-gels containing ferrous cations, ferric cations and chitosan were dropped into a sodium hydroxide solution through a syringe pump. In addition, a sodium hydroxide solution was employed for both gelation (chitosan) and co-precipitati...

Chitosan-coated magnetic nanoparticles (CMNP) were prepared in one-step by precipitation in a high-aqueous phase content reverse microemulsion in the presence of chitosan. The high-aqueous phase concentration led to productivities close to 0.49 g CMNP/100 g microemulsion; much higher than those characteristic of precipitation in reverse microemulsions for preparing magnetic nanoparticles. The o...

Silane modified iron (III) oxide (SiFe2O3) nanoparticles reinforced chitosan (CS) nanocomposite membranes were prepared by solcast transformation method. The iron (III) oxide nanoparticles and nanocomposite membranes were investigated by UV (Visible) spectroscopy, FT-IR spectroscopy, XRD, SEM and TEM. The size and shape of iron (III) oxide and Si-Fe2O3 nanoparticles were determined by XRD and T...