نتایج جستجو برای: chimerism
تعداد نتایج: 2215 فیلتر نتایج به سال:
BACKGROUND Vascularized bone marrow transplantation (VBMT) is widely accepted as an efficient means of establishing chimerism and inducing tolerance. However, the mechanism underlying is poorly understood. Recently, regulatory T cells (Tregs) have been shown to play an important role in regulating immune responses to allogeneic antigens. In this study, we explored the role of Tregs in the induc...
This prospective trial assessed the safety and efficacy of allogeneic hematopoietic stem cell transplantation from a HLA-matched donor with a reduced-intensity regimen (RIST) consisting of iv fludarabine 30 mg/m(2) for 6 days and oral busulfan 4 mg/kg/day for 2 days in patients older than 50 years with hematological malignancies. Cyclosporine alone or cyclosporine with short-term methotrexate w...
To the Editor: We read with interest the editorial by Taylor et al1 concerning the ongoing debate about cardiac chimerism. We were surprised that the authors cited the article of Glaser et al2 as proof that chimerism would not exist but failed to mention our study showing that cardiomyocytes can be regenerated by non-cardiac cells in human transplanted hearts. Importantly, in our article, which...
It has been established that hematopoietic chimerism after double umbilical cord blood transplantation (dUCBT) can predict disease relapse and detect potential engraftment failure. The use of a precise method to evaluate residual host hematopoiesis is imperative because it has been reported that the risk of relapse is higher in patients with mixed chimerism. Up to now, real-time quantitative po...
Nonmyeloablative or reduced-intensity conditioning regimens have been used to condition elderly or ill patients with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). Initial mixed donor/host chimerism (i.e. the coexistence of hematopoietic cells of host and donor origin) has been observed in most patients after such transplants. Here, we describe both factors ...
Ito and coworkers1 describe a model where local irradiation enhances engraftment of CD45 congenic donor bone marrow cells. Their explanation is that the irradiated marrow sites produce cytokines that help proliferation of locally homed stem cells and initiate migration of stem cells to other, nonirradiated sites. This idea sounds appealing because administration of such cytokines would be an id...
Laboratoire de Biologie Cellulaire et Mol~culaire, Centre Hospitalier Universitaire de Poitiers, 86021 Poitiers Cedex, France Allogeneic bone marrow transplantat ion (BMT) is now a c o m m o n t rea tment for hematological diseases. Before the transplantation, the hemopoiet ic cells of the patient are eradicated. In spite of this pretransplant treatment, some apparently normal recipient hemopoi...
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