OBJECTIVE To review the reproductive health knowledge, attitudes, and behaviors of persons with homozygous beta-thalassemia. DESIGN Case-control study. SETTING Patients treated at a tertiary hospital and community-based healthy controls. PARTICIPANT(S) One hundred and thirty persons, 16 years of age or older, who had homozygous beta-thalassemia and were attending hospital for regular bloo...

BACKGROUND & OBJECTIVE Alpha (α) thalassemia is a hereditary disorder and is caused by deletions or mutations in globin genes. It is present in two clinically significant forms: hemoglobin Bart hydrops fetalis (Hb Bart) syndrome and hemoglobin H (HbH) disease. It is highly prevalent in South-East Asia or Mediterranean countries. The most common deletion reported in alpha thalassemia in Pakistan...

Minor beta thalassemia is a common condition in children. The aim of the present study was the investigation of serum tissue transglutaminase IgA level as potential celiac disease in patients with thalassemia minor. This case control study was conducted on patients with beta thalassemia minor and healthy children in the years of 2014 to 2015. A total of 300 children were enrolled and IgA and ti...

To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6-35 months of age in western Kenya. Of children with valid measurements, 71.7% were anemic (hemoglobin < 11 g/dL), 19.1% had ferritin levels < 12 μg/L, and 30.9% had retinol binding protein (RBP) levels < 0....

Background: Atherosclerosis is an important cardiovascular disorder in beta-thalassemia major patients. The present study aimed to predict factors of atherosclerosis in children with beta-thalassemia major. Materials and Methods: This cross-sectional study was conducted on 36 patients with beta-thalassemia major and 36 healthy children as the control group. The carotid intima-media thickness ...

BACKGROUND In sickle cell disease, the quantification of Hb A2 is important for the differential diagnosis between sickle cell anemia (Hb SS) and Hb S/β(0)-thalassemia. OBJECTIVE To determine Hb A2 levels as quantified by high performance liquid chromatography in patients with sickle cell anemia (Hb SS) and with the SC hemoglobinopathy, with or without concomitant alpha thalassemia. METHODS...

β Thalassemia Trait(BTT) produces mild ineffective erythropoiesis and associated increased iron absorption from the gut. Based on these reasons it had been suggested that BTT confers an advantage in maintaining iron balance, in which case prevalence of iron deficiency should be lower in those with the trait. This Study was carried out to determine the frequency of coexistence of iron deficiency...

Thalassemia is viewed as a prevalent inherited blood disease that has gotten exorbitant consideration in the field of medical research around world. Inherited diseases have high risk children will get these from their parents. If both parents are ?-Thalassemia carriers then there 25% chances each child intermediate or major, which most its cases leads to death. Prenatal screening after counseli...