Survival is now the norm for children treated with radiotherapy and chemotherapy for childhood cancers. These children are now living to have children of their own. A Danish study of adverse health outcomes in the offspring of childhood cancer survivors and the offspring of the cancer survivor’s siblings is ongoing. The cumulative probability of congenital malformation is non significantly high...

BACKGROUND The etiology of secondary cancer in childhood cancer survivors is largely unclear. Exposure of normal somatic cells to radiation and/or chemotherapy can damage DNA and if not all DNA lesions are properly fixed, the mis-repair may lead to pathological consequences. It is plausible to assume that genetic differences, i.e. in the pathways responsible for cell cycle control and DNA repai...

BACKGROUND Individuals who had cancer in childhood are at higher risk of developing bone cancer than any other type of second primary cancer. PURPOSE Using the population-based National Registry of Childhood Tumours in Britain, we investigated the incidence and etiology of second primary bone cancer after childhood cancer in a cohort study and in a case-control study. METHODS A cohort study...

BACKGROUND Childhood cancer remains the leading cause of disease-related mortality for children. Whereas, improvement in care has dramatically increased survival, the risk factors remain to be fully understood. The increasing incidence of childhood cancer in Florida may be associated with possible cancer clusters. We aimed, in this study, to identify and confirm possible childhood cancer cluste...

Background Excess weight in adulthood is one of the few modifiable risk factors for pancreatic cancer, and height has associations as well. This leads to question whether body weight and height in childhood are associated with adult pancreatic cancer. Objective To examine if childhood body mass index (BMI; kg/m2) and height are associated with pancreatic cancer in adult life. Methods We lin...

Childhood cancers have different characteristics than those occurring among adults and described as cancers occurring below 15 years of age. In developed countries, its incidence is relatively rare but it's a leading cause of death. More than 80% of the childhood cancers are occurring in low and middle income countries. Based on data from population based cancer registries under National Cancer...

Survivors of childhood cancer are at risk for dental late effects. This systematic review summarizes associations between treatment exposures and dental late effects among survivors of childhood cancer. We included investigations with at least 20 study participants conducted for 2 or more years after completion of childhood, adolescent, or young adult cancer therapy. This review suggests both i...

Introduction: Childhood cancer is a small proportion of all cancers but still major public health problem. Objective: To describe the 5-year incidence and mortality rates net survival childhood in Uruguay. Method: Data on malignant tumors diagnosed children aged 0-14 were included for period 2011-2015, obtained from National Pediatric Registry Cancer Ministry Health Mortality Registry, classifi...