Alkyl-(S,S)-O-lactyllactate was prepared by chemoselective alcoholysis of lactide LA mediated by a magnesium catalyst. When ROH reacted with LA it yielded the ring-opened product R-(S,S)-O-lactyllactate exclusively, which remained intact as long as LA was present in the reaction mixture. Consumption of LA caused the reaction to proceed further giving R-(S)-lactate.

A new approach for preparing (99m)Tc-labelled compounds in high effective specific activity was developed by utilizing a novel fluorous ligand capture (FLC) agent and a chemoselective filtration strategy. This paradigm eliminates the need to use HPLC to obtain technetium(I) based molecular imaging probes free from residual precursor.

Modular peptides displaying both quantum dot bioconjugation motifs and specific subcellular targeting domains were constructed using a chemoselective aniline-catalyzed hydrazone coupling chemistry. Peptides were ratiometrically assembled onto quantum dots to facilitate their specific delivery to either the plasma membrane, endosomes, the cytosol or the mitochondria of target cells.

Using highly stable, readily accessible, and recyclable 2-(2-hydroxyprop-2-yl)cyclohexyl-substituted arylsilanes activated by a mild carbonate base, nickel-catalysed silicon-based aryl-aryl cross-coupling reaction proceeds for the first time with inexpensive aryl chlorides and tosylates in a highly chemoselective manner.

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite((R)) resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are un...

Hydrogenation of benzoic acid using monoand bimetallic catalyst of Ru, Pd, Co, and Re yielded different products. It was observed that 5% Ru/C was an active catalyst for hydrogenation of both aromatic ring and carboxylic group, while Pd/C catalyst hydrogenated only aromatic ring. Ru-Sn/Al2O3 is a chemoselective catalyst for hydrogenation of –COOH group of benzoic acid.

A chemoselective [3+3] cycloaddition of in situ generated azomethine ylides with quinone monoimides has been established, which efficiently led to the construction of dihydrobenzoxazine frameworks with biological relevance, with excellent chemoselectivities and high yields (up to >95 : 5 cr and 98% yield).

To overcome the usually low productivities of the C=C bond bioreduction of α,β-unsaturated aldehydes we combined the in situ substrate feeding product removal (SFPR) technology with a cascade system comprising an isolated ene-reductase and a chemoselective alcohol dehydrogenase.

The remarkable effect of an unsupported nanoporous gold catalyst (AuNPore) on chemoselective hydrogenation of α,β-unsaturated aldehydes using silane has been described. Enals can be reduced with excellent selectivity, giving the corresponding allylic alcohols in good to high chemical yields.