By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted...

Special Announcement (Update 12/11/12): The American Society of Clinical Oncology (ASCO) and the American Urological Association (AUA) have archived this collaborative 2008 guideline on the Use of 5-alpha Reductase Inhibitors for Prostate Cancer Chemoprevention. The guideline has been removed from the main “Clinical Guidance” section of the www.AUAnet.org website, but is available in the “Archi...

Purpose: The development of second primary tumors (SPT) or recurrence alters prognosis for curatively treated head and neck squamous cell carcinoma (HNSCC) patients. The 13-cis-Retinoic acid (13-cRA) has been tested as a chemoprevention agent in clinical trials with mixed results. Therefore, we investigated whether genetic variants in thePI3K/PTEN/AKT/mTORpathway could serve as biomarkers to id...