Thyroid hormones (THs) are required for normal brain and somatic development and for the proper regulation of physiology in both children and adults. Thyroid function is controlled by the dynamic interrelationships between the hypothalamus, the pituitary and the thyroid. These dynamic relationships maintain circulating levels of THs within a narrow range under normal conditions. Normally, there...

-Monoclonal antibody against an osteogenic-sarcoma cell line (791T) was prepared by production and cloning of a somatic-cell hybrid between the mouse myeloma P3-NS1 and spleen cells from 791T-immunized mice. Three clones of a hybridoma producing antibody against 791T, as detected by 1251-labelled Protein A binding, were tested against a range of normal and tumour cell targets to determine the p...

2.1 Types and Amounts Present. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 Distribution, Transport and Transformation. . . . . . . . . . . . . . . . . . . . . . . . . 2.3 Uptake by Biota. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , . . . 2.4 Fate in the Environment. . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

A number of environmental chemicals, by mimicking natural hormones, can disrupt endocrine function in experimental animals, wildlife, and humans. These chemicals, called "endocrine-disrupting chemicals" (EDCs), are such a scientific and public concern that screening and testing 58,000 chemicals for EDC activities is now statutorily mandated. Computational chemistry tools are important to biolog...

We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less t...

Many of the > 83,000 chemicals currently used in commerce pose potential toxic hazards to human health and the environment. Numerous policies and systems are in place to try to identify harmful chemicals that are already in use, but removing these problem chemicals once they are already in the marketplace can be difficult, time-consuming, and costly. In an ideal world, chemists would be able to...