Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing ...

A comparison of analogous benzoquinonediimide protein cleavage reagents is presented. While the 2-methoxy derivative reveals no apparent advantage over the previously reported 2-methyl-N’-benzenesulfonyl-N4-bromoacetyl-benzoquinonediimide (Cyssor I ; Sigma Chemical Company), the 2-chloro analogue reveals significant cleavage of ovalbumin under identical solvent conditions, but without the appli...

1. Advantages of Chemical Redox Agents 878 2. Disadvantages of Chemical Redox Agents 879 C. Potentials in Nonaqueous Solvents 879 D. Reversible vs Irreversible ET Reagents 879 E. Categorization of Reagent Strength 881 II. Oxidants 881 A. Inorganic 881 1. Metal and Metal Complex Oxidants 881 2. Main Group Oxidants 887 B. Organic 891 1. Radical Cations 891 2. Carbocations 893 3. Cyanocarbons and ...

Graphene Based Materials In article 2100866, Helm and co-workers review that RNA nucleobases are known to feature intrinsic reactivity towards a number of chemical reagents from organic chemistry but also occurring in our environment. Some allow discriminate canonical modifications.

Bioluminescence whereby light is emitted as a result of a chemical reaction offers several advantages over other assay methods, such as fluorescence, including low background and the utilization of reagents with extended shelf life [1]. Also, since no filters or excitation sources are needed, lab-on-chip integration is considerably easier. Of special interest are luciferase-based assay methods ...

Antibody conjugates are widely used as diagnostics and imaging reagents. However, many such conjugates suffer losses in sensitivity and specificity due to nonspecific labeling techniques. We have developed methodology to site-specifically conjugate oligonucleotides to antibodies containing a genetically encoded unnatural amino acid with orthogonal chemical reactivity. These oligobody molecules ...

The use of heterogenization as a method for achieving clean synthesis is discussed. The chemical modification of mesoporous solids can be used to make a range of catalysts, including solid acids and bases, and stable metal complexes for selective oxidations and other reactions. By avoiding an aqueous quench stage in the separation, the heterogenization of catalysts and reagents can lead to subs...

In the study of photochemical reactions laser pulses serve as both reagent and measuring device. The role of measuring device has been exemplified by ultrafast spectroscopies that exploit broadband optical pulses to probe molecular dynamics with femtosecond time resolution. More sophisticated multi-dimensional spectroscopies are using optical pulse-shaping to take measurement of molecular level...

Fundamental and applied research in chemistry and biology benefits from opportunities provided by droplet-based microfluidic systems. These systems enable the miniaturization of reactions by compartmentalizing reactions in droplets of femoliter to microliter volumes. Compartmentalization in droplets provides rapid mixing of reagents, control of the timing of reactions on timescales from millise...

Latex-Ficus carica var. Kadota latex was collected from the green fruit of trees grown in the orchard of Mr. V. Ed Scott of Planada, California, as described (1). Subsequent storage and centrifugation have also been described (1). Reagents-Carnation instant nonfat dry milk was used for milk-clotting activity determinations. Barbital was obtained from Mallinckrodt Chemical Works, St. Louis, Miss...