Topical application of natural antioxidants has proven to be effective in protecting the skin against ultraviolet-mediated oxidative damage and provides a straightforward way to strengthen the endogenous protection system. However, natural products can provoke skin adverse effects, such as allergic and irritant contact dermatitis. Skin irritation potential of Castanea sativa leaf ethanol:water ...

Polyphenols (tannins) in the diet not only precipitate oral proteins, producing an astringent sensation, but also interact with dietary proteins and digestive enzymes in the gut, resulting in a variety of antinutritive and toxic effects. Salivary proline-rich proteins (PRPs), which are secreted into the oral cavity, form complexes with and precipitate dietary polyphenols, and thus, they constit...

In the present study, the effect of seed priming with magnetic field (MF; 45, 90, 200 and 250mT for 5, 10, 20 and 30 min) was evaluated in 60-day-old Hyssopus officinalis plants grownunder 8 days irrigation intervals. The assessments were consisted of biomass, membranestability, photosynthetic pigments concentrations, polyphenols content, antioxidant enzymesactivities an...

Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-au...

The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic co...

T HE GLOBAL PANDEMIC OF TYPE 2 DIABETES mellitus places an incalculable burden on health care systems. In the United States alone, it is estimated that 52% of the population will have diabetes or prediabetes by 2020, conditions that already cost that country $194 billion a year in health care spending. Amelioration of type 2 diabetes mellitus risk usually targets lifestyle and diet, primarily w...