BACKGROUND Chelation therapy has emerged as a popular treatment modality to remove heavy metals that are thought to cause autism. We report a fatality that occurred as a consequence of chelation therapy for autism when the incorrect form of EDTA was administered. CASE REPORT A five-year-old autistic male was being chelated in a physician's office. While receiving his third treatment he went i...

The reaction of Mn(OAc)2 x 4H2O with 2,6-dimethoxybenzoylsalicylhydrazide (H3dmbshz) leads to a dodecanuclear manganese metallamacrocycle [Mn12(dmbshz)12(EtOH)6], 1. The successive manganese centers are connected by the hydrazide N-N groups of the ligands in an alternating pentadentate binding mode, hexadentate binding mode. The alternation results in two alternating chelation modes around the ...

OBJECTIVES The purpose of this study was to determine the mechanism by which iron chelation affects the trophozoite survival of Entamoeba histolytica. Fe2+ is a cofactor for E. histolytica alcohol dehydrogenase 2 (EhADH2), an essential bifunctional enzyme [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] in the glycolytic pathway of E. histolytica. METHODS We tested the effects ...

// Gina Abdelaal 1 and Stephany Veuger Department of Applied Sciences, Faculty Health Life Northumbria University, Newcastle upon Tyne, UK Correspondence to: Abdelaal, email: [email protected] Keywords: iron chelator; oncogenesis; selective cytotoxicity; hallmarks cancer; NDRG1 Received: September 29, 2020     Accepted: December 16, Published: January 19, 2021 ...

Background Regular transfusion in thalassemia major patients increases life expectancy and improves quality of life, but results in iron overload, which had toxic effects to organs including endocrine glands. The introduction of iron chelation therapy has reduced its toxicity, but complications may still occur. In Indonesia, most of our patients did not receive optimal iron chelation therapy, w...

1,2-Dithiooxalate (dto) can be employed as a bridging ligand and gives symmetric ( O , S -chelation) or asymmetric - coordination modes. In this study, we have prepared novel dto-bridged diiron(II)...