Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD pat...

c 2018 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 24 No. 2 April, 2018 www.jnmjournal.org TO THE EDITOR: Combined esophageal pH monitoring and multichannel intraluminal impedance (pH-MII) permits the analyses of bolus exposure during volume clearance and acid neutralization during chemical clearance. pH-MII has become particularly important for det...

OBJECTIVES It is presently recommended that oral feeding be started in premature infants as soon as possible, often at an age at which nasal continuous positive airway pressure (nCPAP) is still required for ventilatory support. Our previous data showed that application of nCPAP up to 10 cmH2O in full-term lambs had no deleterious effect on cardiorespiratory safety, feeding efficiency, or on nut...

Background: Esophageal pH monitoring in conjunction with multichannel intraluminal impedance (MII-pH) is now considered the most accurate method for detection and characterization of gastro-esophageal reflux (GER), with higher sensitivity and specificity in detecting reflux than esophageal pH monitoring alone. Aims: One possibly limiting factor for using MII-pH testing is the time required to a...

AIMS To assess the contribution of 24-h esophageal multichannel intraluminal impedance and pH (MII-pH) monitoring and high resolution endoscopy (HRE) with i-scan imaging in differentiating non erosive reflux disease (NERD) from functional heartburn (FH). METHODS This is a retrospective cohort study of patients with heartburn from the Endoscopy Unit. NERD patients and FH patients were defined ...

BACKGROUND None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS Two hundred and fifty patients with symptoms suggestive of GERD and 35 asym...

BACKGROUND An international group of experts evaluated and revised recommendations for ambulatory reflux monitoring for the diagnosis of gastro-esophageal reflux disease (GERD). METHODS Literature search was focused on indications and technical recommendations for GERD testing and phenotypes definitions. Statements were proposed and discussed during several structured meetings. KEY RESULTS ...

PURPOSE The aim of this study was to evaluate bolus transit during esophageal swallow (ES) and gastroesophageal reflux (GER) events and to investigate the relationship between the characteristics of ES and GER events in a population of term and preterm newborns with symptoms of gastroesophageal reflux disease (GERD). METHODS The study population consisted of term and preterm newborns referred...

OBJECTIVES/HYPOTHESIS To determine salivary pepsin levels as a function of collection time. STUDY DESIGN A prospective, case-control study. METHODS We selected 57 patients with clinical symptoms and signs of laryngopharyngeal reflux who underwent 24-hour multichannel intraluminal impedance-pH (24h MII-pH) monitoring tests, and 12 control subjects without clinical symptoms and signs of laryn...