Class I products of the major histocompatibility complex (MHC) comprise a heavy chain of about 45 kDa noncovalently linked to a 12-kDa beta 2-microglobulin (beta 2m) light chain encoded on a different chromosome. We find that class I products of some mouse strains include an additional 62-kDa molecule which on the following evidence consists of a heavy chain linked covalently with beta 2m. Prod...

The first-principles simulation of the electronic structure organic semiconductors in solution poses a number challenges that are not trivial to address simultaneously. In this work, we investigate effects and mutual interplay solvation, alkylization, doping on structural, electronic, optical properties sexithiophene, representative semiconductor molecule. To end, employ (time-dependent) densit...

Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections. They are primarily immunoglobulin M (IgM) and bind a variety of structurally dissimilar self and exogenous antigens (Ags) with moderate affinity. We analyzed the contribution of Ig polyvalency and of heavy (H) and light (L) c...

Staphylococcus epidermidis is a harmless human skin colonizer responsible for ~20% of orthopedic device-related infections due to its capability to form biofilm. Nowadays there is an interest in the development of anti-biofilm molecules. Marine bacteria represent a still underexploited source of biodiversity able to synthesize a broad range of bioactive compounds, including anti-biofilm molecul...

Magnetic properties of a Heisenberg diamondlike spin chain model for purely organic molecule-based ferrimagnets are investigated by means of the many-body Green's function method within random phase approximation. The molecule-based ferrimagnet is composed of S=1 biradical and S=1/2 monoradical molecules alternating with intermolecular antiferromagnetic (AF) interactions, and the S=1 site is co...

Procedures for the preparation of soluble collagen from rat skin and tail tendon were reviewed and revised to permit the preparation of native monomeric collagen with intact nonhelical ends. The degree of intactness was estimated from the tyrosine content, which is present only in the nonhelical ends, and by mobility of the COOH-terminal cyanogen bromide peptide of the alpha1 chain on sodium do...

The crystal structure of encorafenib, C 22 H 27 ClFN 7 O 4 S, has been solved and refined using synchrotron X-ray powder diffraction data, optimized density functional theory techniques. Encorafenib crystallizes in space group P 2 1 (#4) with a = 16.17355(25), b 9.52334(11), c 17.12368(19) Å, β 89.9928(22)°, V 2637.50(4) Å 3 , Z 4. consists alternating layers stacked halogenated phenyl rings th...

Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S now well described essential molecule that finely balanced to maintain cellular functions, especially modulating mitochondrial activity. Mitochondria are responsible for the oxidation of safe elimination...

auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. in the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...

in the present paper, resonant frequencies and modes of a three-atom photonic molecule and a photonic crystal placed within a cavity are numerically calculated. first, governing formulation in transverse electric field mode (te) is obtained using maxwell equations. then, an algorithm based on a finite difference scheme and matrix algebra is presented. the algorithm is then implemented in a comp...