BACKGROUND Alcohol causes fetal alcohol spectrum disorders in part by disrupting the function of the neural cell adhesion molecule L1. Alcohol inhibits L1-mediated cell-cell adhesion in diverse cell types and inhibits L1-mediated neurite outgrowth in cerebellar granule neurons (CGNs). A recent report indicates that ethanol (EtOH) induces the translocation of L1 into CGN lipid rafts and that dis...

In some instances, Service Providers (SPs) have a legal logging requirement to be able to map a subscriber's inside address with the address used on the public Internet (e.g., for abuse response). Unfortunately, many logging solutions for Carrier-Grade NATs (CGNs) require active logging of dynamic translations. CGN port assignments are often per connection, but they could optionally use port ra...

Background and objectives: Alzheimer's disease (AD) as a neurodegenerative disorder is the most common form of dementia in the elderly. According to the amyloid hypothesis, accumulation of amyloid beta (Aβ) plaques, which are mostly constituted of Aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. Thus, modulation of Aβ toxicity is the hopef...

With increased computational power and progress in numerical methods over the past several decades, Computational Fluid Dynamics (CFD) is now used routinely as a powerful tool in the design of aircraft. Current production CFD codes used in the aerospace industry are usually second order accurate. High-order methods have the potential to achieve higher accuracy at less cost than low-order method...

After neurotransmitter release in central nerve terminals, SVs are rapidly retrieved by endocytosis. Retrieved SVs are then refilled with neurotransmitter and rejoin the recycling pool, defined as SVs that are available for exocytosis(1,2). The recycling pool can generally be subdivided into two distinct pools - the readily releasable pool (RRP) and the reserve pool (RP). As their names impl...

Slow synaptic potentials are generated when metabotropic G-protein-coupled receptors activate heterotrimeric G-proteins, which in turn modulate ion channels. Many neurons generate excitatory postsynaptic potentials mediated by G-proteins of the G q/11 family, which in turn activate phospholipase C. Accessory GTPase-activating proteins (GAPs) are thought to be required to accelerate GTP hydrolys...

Human immunodeficiency virus dementia (HIV-D) is a nonfocal central nervous system manifestation characterized by cognitive, behavioral, and motor abnormalities. The pathophysiology of neuronal damage in HIV-D includes a direct toxic effect of viral proteins on neuronal cells and an indirect effect caused by the release of inflammatory mediators and neurotoxins by activated macrophages/microgli...