AIM To correlate the baseline and change of chromogranin A (CgA) levels with patient survival and tumor response in Asian patients with advanced gastro-enteropancreatic neuroendocrine tumors (GEP-NETs). PATIENTS AND METHODS Sixty patients with advanced GEP-NET treated in a medical center between April 2010 and April 2013 were enrolled retrospectively. Plasma CgA level was analyzed for correla...

In previous papers [1,2] relating to the concept of Combined Gravitational Action (CGA) we have established the CGA-theoretical foundations as an alternative gravity theory that already allowed us to resolve -in its contextsome unexpected and defiant problems occurred inside and outside the Solar System like, e.g., the anomalous Pioneer 10’s deceleration; the observed secular increase of the As...

The compact Genetic Algorithm (cGA) is an Estimation of Distribution Algorithm that generates offspring population according to the estimated probabilistic model of the parent population instead of using traditional recombination and mutation operators. The cGA only needs a small amount of memory; therefore, it may be quite useful in memory-constrained applications. This paper introduces a theo...

OBJECTIVES To construct and validate a frailty index (FI) that is clinically sensible and practical for geriatricians by basing it on a routinely used comprehensive geriatric assessment (CGA) instrument. DESIGN Secondary analysis of a 3-month randomized, controlled trial of a specialized mobile geriatric assessment team. SETTING Rural Nova Scotia. Participants were seen in their homes. PA...

PURPOSE To evaluate whether the pretreatment determination of serum chromogranin A (CgA) can provide information beyond that obtained with serum prostate specific antigen (PSA) and Gleason score at biopsy as a predictive factor of clinical understaging (T2-pT3) of prostate adenocarcinoma. MATERIALS In this prospective study, we analyzed 83 consecutive patients with clinical T2N0M0 prostate ad...

Chromogranins (Cg) are large acidic proteins, co-stored with amines or peptides in the secretory granules of a wide variety of paraneurons. By immunohistochemistry performed on serial semithin sections, the distribution of Cg in the gastroenteropancreatic (GEP) system was analyzed in the endocrine pancreas of 10 mammalian species and in enteroendocrine cells of 6 species. Of the Cg families, Cg...

BACKGROUND With regard to the growing proportion of elderly multimorbid patients, a sound undergraduate geriatric education becomes more important. Therefore we included the execution and interpretation of a comprehensive geriatric assessment (CGA) into a mandatory two-week clerkship at a general practitioner's office. The present study examined the effect of a guide structuring the students' c...

Lysophosphatidylcholine (LPC) is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL) and is implicated in its atherogenic activity. This study investigated the effects of LPC on cell viability, intracellular calcium homeostasis, and the protective mechanisms of chlorogenic acid (CGA) in human umbilical vein endothelial cells (HUVECs). LPC increased intracellular calcium ...

32 33 Chromogranin A (CgA) is widely expressed in endocrine and neuroendocrine tissues as well as in the central 34 nervous system. We observed CgA expression (mRNA and protein) in the gastrocnemius (GAS) muscle and 35 found that performance of CgA-deficient Chga-KO mice in treadmill exercise was impaired. Supplementation 36 with CgA in Chga-KO mice restored exercise ability suggesting a novel ...