Introduction/Background Cervical cancer (CC) is one of the most common types and fourth leading cause cancer-related deaths in women. carcinogenesis multistep process cervical dysplasia development progression. Correct diagnostic effective therapy presents an important approach to reduce CC morbidity mortality. MicroRNAs epithelium cells are considered as promising markers dysplasia. M...

The aim of this study was to explore the correlation of ezrin and galectin-3 expressions with prognosis in cervical cancer. The immunohistochemical method was applied to detect ezrin and galectin-3 expressions in normal cervix tissues (n=30), cervicitis tissues (n=28), cervical intraepithelial neoplasia (CIN) tissues (classified as I-III, n=89), and cervical carcinoma tissues (n=84). Follow-up ...

There are several differences between neuroendocrine and other types of cervical cancer, in prognosis, diagnosis and treatment. Neuroendocrine cancer of the uterine cervix is a rare and aggressive disease. Small cell carcinoma is classified as a neuroendocrine tumor in the currently used World Health Organization histological classification of tumors of the uterine cervix (2003). Small-cell car...

Chemoradiation is the current standard of care in patients with locally advanced carcinoma cervix. Although extensive literature is available on the acute morbidity due to chemoradiotherapy in women with cancer cervix, most of the studies have been done at carefully prepared academic centers in developed countries (Rose et al., 1999; Maduro et al., 2003; Ikushima et al., 2006; Mahantshetty et a...

Cervical cancer remains a significant health problem. New strategies based on the molecular aspects of cervical carcinogenesis are needed. Chemoprevention represents a novel strategy for cervical cancer prevention. Our group plans phase I and II trials using alpha-difluoromethylornithine, a suicide inhibitor of ornithine decarboxylase and potent antiproliferative chemopreventive agent. We condu...

Given the extended survival of patients diagnosed with cervical cancer, a large number of women are treated with radiotherapy. A second primary cancer has currently become one of the most important radiation-induced injuries as the number of cancer patients who are cured is increasing by virtue of recent advancements in therapeutic radiology. A 56-year-old woman developed two pelvic malignancie...

Individuals with a low level of a-tocopherol are at increased risk of cancer as compared to those with a higher level. We conclucted a case control study to evaLuate this fact in patients with carcinoma of the cervix and to propose guidelines for elesigning further trials. Serum vitamin E levels were estimated in 50 normal women and 50 patients of histologically proven carcinoma of the cervix b...

A Pap smear, also known as Papanicoloau smear, is a microscopic examination of cells scraped from the cervix and is used to detect cancerous or pre-cancerous conditions of the cervix or other medical conditions. It was named after Dr. George N. Papanicoloau, who first described it in 1928 and since its introduction, the Pap smear has helped reduce cervical cancer incidence and mortality rates b...

Death-rates from cancer of the cervix in the United States in 1950-67 are compared with similar data for England and Wales. In the United States (unlike England and Wales) statistics show no evidence of a rise in mortality-rates for cancer of the cervix among women under 60 years: they show a decline in all 10-year age-groups from 30 to 79 among White women; among non-White women a similar decl...

1. Treatment of CIN 2. Invasive Carcinoma of the Cervix 1. Clinical presentation 2. Staging 3. Histology 4. Management 1. Stage 1A 2. Stage IB – 2A 3. Stage 2B – 4A 4. Stage 4B 5. Complications 1. Radical Hysterectomy 2. Radiotherapy 6. Minimal Access Surgery 1. Laparoscopic Vaginal Radical Hysterectomy (LVRH) 7. Fertility Sparing Surgery 8. Special Situations 1. Recurrent Cervical Cancer 2. In...