Cellular self-eating promotes pancreatitis T o survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries it to the lysosome for digestion. The process is often b...