BACKGROUND AND PURPOSE Our purpose was to determine the brain MR imaging characteristics of merosin-deficient congenital muscular dystrophy in children. METHODS We reviewed the MR imaging findings of the brain in three children with known merosin-deficient congenital muscular dystrophy to determine the presence of any cerebral or cerebellar abnormalities of development or abnormalities of the...

One of the fundamental problems posed by multiple sclerosis is concerned with the distribution of the pathological lesions called plaques. The literature concerning the histopathology of this disease is immense but a recent review by Lumsden (1955) did not refer to any paper in which the position of plaques in the cerebrum had been determined with any exactitude although such an exact study was...

Neocortical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are basal progenitors derived from ventricular apical radial glia (aRG) that selectively lose their apical processes. bRG and BG have been implicated in the expansion and folding of the cerebrum and cerebellum, respectively. Here, we analyzed the molecular characteristics and development of bRG and BG. Transcriptomic comparis...

The effect of 90 minute supine restraint or forced swim stress, on weights of various organs in sixty adult male albino rats was studied. One group of twenty rats served as control; second group of twenty was immobilized and third group of twenty was forced to swim in water at room temperature. The animals were studied for a period of 15 days. During this period, they were subjected to 90 minut...

Gravid Nya: NYLAR strain mice were infected with Toxoplasma gondii on embryonic day 7. During the remaining 12 days of gestation, considerable fetal wastage occurred. At birth, pups were sickly and growth-stunted, and postnatal mortality was high. After 1 month, surviving weanlings were killed and autopsied. Coronal sections of the cerebrum revealed: numerous cortical and periventricular cystic...

In order to assess the nature of glial fibrillary acidic protein (GFAP) immunoreactivity in the radial glia of early human fetal cerebrum, full thickness blocks from the midconvexity of the frontoparietal region of the cerebrum of 25 human fetuses ranging from ten to 20 weeks of ovulation age were studied by light and electron microscopic (EM) immunoperoxidase methods. The presence of GFAP with...

A 2-year-old male cynomolgus monkey (Macaca fascicularis) showed neurological symptoms during quarantine for importation into Japan, and was euthanized due to poor prognosis. Gross anatomical examination revealed a hemorrhagic lesion around the lateral ventricle in the cerebrum. Histologically, severe diffused suppurative meningitis and ventriculitis were detected with numerous Gram-negative ba...