1. Anaesthetized, nephrectomized rats were infused intravenously with unlabelled angiotensin II (AII) or with [3H]angiotensin II (3H-labelled AII). The brain ventricular system was perfused with artificial cerebrospinal fluid. The perfusate was collected from the cisterna magna and analysed for AII by radioimmunological and biochemical methods. 2. No increase of immunoreactive AII in cerebrospi...

This study relates the level of alpha and gamma enolase in cerebrospinal fluid sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Twenty-eight patients were studied, two with transient ischaemic attacks and 26 with completed stroke due to infarction. The cerebrospinal fluid enolase was raised in the two pa...

The free amino-acids normally present in cerebrospinal fluid are leucine, valine, alanine, glycine, serine, and glutamine. The concentration of each amino-acid is much less than that found in plasma, with the exception of glutamine, which is in higher concentration in the cerebrospinal fluid. Walshe (1951) examined the cerebrospinal fluid of three patients in hepatic coma by paper chromatograph...

Oxidative damage occurs in multiple sclerosis, but is difficult to identify antemortem and remains an unknown contributor to disease progression. Carbonylation is a quantitative measure of protein oxidation. Cerebrospinal fluid samples from multiple sclerosis patients showed elevated carbonylated protein levels compared to controls. In experimental autoimmune encephalomyelitis, carbonylated pro...

In a study of 21 patients with disease of the central nervous system IgA, which is normally absent, could be detected in the cerebrospinal fluid in the presence of meningitis of bacterial or fungal origin: the concentration of IgA in the cerebrospinal fluid could not, however, be correlated with serum levels. A reaction of non-identity has been demonstrated between serum and cerebrospinal fluid...

1. Kronholm V, Lintrup J. Spectrophotometric investigation of the cerebrospinal fluid in the near-ultraviolet region. Acta Psychiatr Neurol Scand 1960;35: 314–29. 2. Buruma OJS, Janson HLF, van den Bergh FAJTM, Bots GTAM. Blood stained cerebrospinal fluid: traumatic puncture or haemorrhage? J Neurol Neurosurg Psychiatr 1981;44:144–7. 3. Vermeulen M, Gijn van J, Bleijenberg BG. Spectrophotometri...

Introduction: Recent studies point to the clinical and research efficacy of saliva as a respected diagnostic aid for observing Multiple Sclerosis. The objectives of this Hypothesis are to identify novel biomarkers recognized to Multiple Sclerosis in early stage in saliva and to determine if the levels of these markers correlate with level of these Cerebrospinal fluid and blood assays and urine ...

The charts of 750 patients were reviewed to determine the value of routinely removing cerebrospinal fluid at the time of myelography and cisternography for chemical and cytologic examination. In most patients cerebrospinal fluid findings were normal. In the few abnormal studies, the findings were often uninformative, superfluous, or insufficient for appropriate diagnosis. In no instance did rou...

Neuropeptides are present in brain tissue as well as in cerebrospinal fluid. Studies from a variety of disciplines have demonstrated that neuropeptides have neuromodulatory activities. Such activities are apparent in the involvement of neuropeptides in the regulation of adaptive, autonomic, and endocrine functions of the brain. Neuropeptides exert their neuromodulating influences by acting as n...