BACKGROUND AND PURPOSE Several recent studies analyzing perfusion changes in acute intracerebral hemorrhage fed the debate whether there is secondary ischemic tissue damage in the vicinity of intracerebral hemorrhage. We used perfusion CT to address this question. METHODS We examined 36 patients between 2001 and 2002 with acute intracerebral hemorrhage (within 24 hours after symptom onset). A...

BACKGROUND AND PURPOSE The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL APPROACH Cerebral perfusion was quantified using bolus-tracking arterial spin labelling (btASL) MRI. Rats received MDMA (20 mg·kg(-1); i.p.) and were assessed 1, 3 or 24 h la...

Various methods of cerebral protection have been used during such aortic arch operations as the Norwood Procedure and operations on the interrupted aortic arch in neonates and infants. Deep hypothermia with circulatory arrest is the most common technique, but has a limited safe period for circulatory arrest. Antegrade cerebral perfusion has been introduced to prolong this safe period. We review...

Tomographic images of cerebral blood flow (CBF) and oxygen extraction fraction (OEF) using the 15O continuous inhalation technique, and positron emission tomography, were obtained from a patient with cerebral ischemia distal to an occluded left internal carotid artery. There was a focal mismatch between CBF and oxygen metabolism in the brain supplied by the middle cerebral artery where CBF was ...

ARTERIAL STENOSIS, thrombosis, embolization and vasospasm often produce a reduction in regional brain perfusion to levels which result in focal cerebral ischemia. The metabolic consequences of this ischemic insult produce neurologic deficits which may be reversible or irreversible, depending Upon both the depth and duration of the ischemia. Therefore, the study of factors influencing cerebral b...

Introduction:Amphetamines are central nervous system (CNS) stimulant substances and amphetamine abuse is considered a growing problem in our country. Previous studies revealed destructive effects of amphetamines on metabolism, perfusion and structure of brain. The aim of current study was evaluating regional cerebral blood flow (rCBF) disturbances in methamphetamine (MA) abuser...

BACKGROUND AND PURPOSE White-matter hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small-vessel disease and neurodegenerative changes. We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cer...

BACKGROUND Continuous monitoring of dynamic cerebral autoregulation, using a moving correlation index of cerebral perfusion pressure and mean middle cerebral artery flow velocity, may be useful in patients with severe traumatic brain injury to guide treatment, and has been shown to be of prognostic value. OBJECTIVE To compare an index of dynamic cerebral autoregulation (Mx) with an index of s...

The mechanisms underlying cerebral microvascular perfusion deficit resulting from occlusion of the middle cerebral artery (MCA) require elucidation. We, therefore, tested the hypothesis that intravascular fibrin deposition in situ directly obstructs cerebral microcirculation and that local changes in type 1 plasminogen activator inhibitor (PAI-1) gene expression contribute to intravascular fibr...

687±92 2 Dewey RC, Pieper HP, Hunt WE. Experimental cerebral hemodynamics. Vasomotor tone, critical closing pressure, and vascular bed resistance. J Neurosurg 1974; 41: 597±606 3 Aaslid R, Lundar T, Lindegaard K-F, Nornes H. Estimation of cerebral perfusion pressure from arterial blood pressure and transcranial Doppler recordings. In: Miller JD, Teasdale GM, Rowan JO, Galbraith SL, Mendelow AD,...