Both control rats and rats with neurotoxic lesions of the amygdala central nucleus ate more food during presentations of a conditioned stimulus (CS) previously paired with food than during an unpaired CS. This potentiation occurred regardless of whether the food was presented in its usual place or in a different location. By contrast, rats with neurotoxic lesions of basolateral amygdala showed ...

abstractintroduction: previous investigations have shown that protein malnutrition can alters the structure and function of some areas of hippocampal formation. we investigated the effect of protein malnutrition on amygdaloid projections to the ca1 hippocampal area. in this study we investigated level and pattern of distribution of efferent projections from amygdala to hippocampus in the rat by...

Contemporary economic models hold that instrumental and impulsive behaviors underlie human social decision making. The amygdala is assumed to be involved in social-economic behavior, but its role in human behavior is poorly understood. Rodent research suggests that the basolateral amygdala (BLA) subserves instrumental behaviors and regulates the central-medial amygdala, which subserves impulsiv...

The relationship between FOS production in the sensory cortex and limbic system and the ability of C57BL/6N mice to acquire context- and tone-dependent freezing were investigated after fear conditioning, which was achieved by exposure of mice to context only or context and tone (10 kHz, 75 dB) as conditioned stimuli (Cs) paired with an electric footshock (0.7 mA, constant) as unconditioned stim...

BACKGROUND The antianxiety effects of ethanol appear to be a crucial factor in promoting alcohol intake. Regulation of gene expression by microRNA (miRNA) is an important epigenetic mechanism that affects neuronal pathways and behaviors. We investigated the role of miRNAs underlying the mechanisms of ethanol-induced anxiolysis. METHODS Acute ethanol-induced anxiolysis was measured in adult ra...

............................................................................................ 13 Introduction...................................................................................... 15 Fear and Anxiety............................................................................... 18 Models............................................................................................. ...

Anxiety disorders are the most prevalent central nervous system diseases imposing a high social burden to our society. Emotional processing is particularly controlled by GABA-ergic transmission in the amygdala. Using in situ hybridization and immunohistochemistry we now investigated changes in the expression of GABA synthesizing enzymes (GAD65 and GAD67), GABA(A) (α1-5, β1-3, γ1-2) and GABA(B) ...

background and objectives cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. there are also functional interactions between both cannabinoid and opioid systems. in this study we investigated the role of cannabinoid receptors in central amygdala and its interaction with opioid system.   methods in the present study, we investigated the ...

epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. it has been shown that each seizure has a depressing effect on the following seizure. thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. in this study, the role of adenosine a1 receptors in pos...