catharanthus roseus is a medicinal and ornamental plant with growing attention toward its economical value. cell suspension from c. roseus were treated with 0 to 60mm of cadmium nitrate for 1, 3 and 6 days, then cell viability was determined using trypan blue and mtt assay. cell morphology was investigated using 0, 10, 30 and 50 mm of cadmium nitrate as selected dose for 3 days. callus of c.ros...

BACKGROUND Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing s...

background: boric acid (ba) is commonly used as pesticide, disinfectant and wood preservative. its ingestion can cause serious organ damages resulting in death. case report: a 19 year old man was found dead with two empty packs of ba tablets in vicinity of his body. on autopsy examination, brownish stains along with right angle of mouth and right nostril were found. stomach was damaged with hem...

Radiotherapy is an effective treatment strategy for cancer, but a significant proportion of patients experience radiation-induced toxicity due to damage to normal tissue in the irradiation field. The use of chemical or biological approaches aimed at reducing or preventing normal tissue toxicity induced by radiotherapy is a long-held goal. Hypoxia-inducible factors (HIFs) regulate the production...

paracetamol (acetaminophen, pcm) is a widely used over-the-counter analgesic and antipyretic drug. intake of a large dose of pcm may result in severe hepatic necrosis. oxidative stress is mediated by oxidative capacities of the pcm metabolite (n-acetyl-para-benzo quinoneimine, napqi), which covalently binds to proteins and other macromolecules to cause cellular damage. at low doses, napqi is co...

A hallmark of protein conformational disease, exemplified by neurodegenerative disorders, is the expression of misfolded and aggregated proteins. The relationship between protein aggregation and cellular toxicity is complex, and various models of experimental pathophysiology have often yielded conflicting or controversial results. In this study, we examined the biophysical properties of amyotro...

Toxicity bioassays are important tools to determine biological effects of chemical agents on species. The questions remained on, what effects have been imposed on each of the different molecular site of cells by chemical exposure and how to find a pattern for chemical toxicity. To address the questions, HepG2 cell lines were exposed to the different concentrations of cisplatin for 24 hours to r...