Cellular gene delivery via polycations has wide implications for the potential of therapy, but it remained a challenge due to plethora pre- and post-uptake barriers that must be overcome reach desired efficiency. Herein we report poly(hexamethylene biguanide) (PHMB) as nano-vector intracellular plasmid DNA (pDNA) oligodeoxynucleotides (ODNs). PHMB pDNA or ODNs self-assembled into complex nanopa...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

the field of vaccinology provides excellent promises to control different infectious and non-infectious diseases. genetic immunization as a new tool in this area by using naked dna has been shown to induce humoral as well as cellular immune responses with high efficiency. this demonstrates the enormous potential of this strategy for vaccination purposes. dna vaccines have been widely used to de...

naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

Abstract Heat shock protein 70 kDa (HSP70) is a major family in the cell protections against stress-induced denaturation and aggregation folding of nascent proteins. It highly conserved that can be found most organisms strongly connected to several intracellular pathways such as refolding, degradation regulation, protection intense stress. Cellular delivery HSP70 would high impact for clarifica...