According to recent research reports, addition of small amounts of a secondary fluid to a suspension could dramatically increase viscosity of suspension. Results of this study indicate another interesting behavior that the secondary fluid could form a thin hydrophobic membrane around particle surface and significantly decrease the viscosity and yield stress of the suspension. To enhance the sur...

Amitriptyline hydrochloride is a highly permeable active pharmaceutical ingredient (API). The function of these drugs is to block the reuptake of the neurotransmitters, norepinephrine and serotonin in the central nervous system. The nano-sized Amitriptyline (AT) imprinted polymer particles were synthesized successfully. The nanoparticles were characterized by Fourier transform infrared spectros...

to develop an optimal bioprocess for benzophenanthridin alkaloids production, various metabolite engineering are studied to increase yields, in which one of them is elicitation. elicitors are biotic or abiotic molecules that have effectively stimulated the production of plant secondary metabolites in cell and organ cultures. since this plant serves as the only commercial source of morphine and ...

BACKGROUND We have previously shown that hyperforin, a phloroglucinol derivative found in St. John's wort, behaves as a potent anti-angiogenic compound. To identify the reactive group(s) mainly involved in this anti-angiogenic effect, we have investigated the anti-angiogenic properties of a series of stable derivatives obtained by oxidative modification of the natural product. In addition, in t...

The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavonoid constituents; hypericin is also reported to ...