Insulinomas cause neuroglycopenic symptoms, permanent neurological damage and even death. Current available therapies cannot satisfactorily treat malignant insulinomas and some benign insulinomas. The promising phototherapeutic results and harmless side effects of hypericin in some cancer treatments prompted us to explore possible anti-growth activity of photoactivated hypericin against RINm5F ...

Treatment of childhood rhabdomyosarcoma is limited by recurrent disease and the development of multidrug resistance. Therefore, novel treatment options are desirable. Photodynamic therapy (PDT) using the photodynamic agent hypericin is proposed as an alternative approach for intraoperative visualization and treatment of this disease. The aim of this study was to investigate in vitro effects of ...

We analyzed the relationship among microvessel density (MVD) and tumor infiltrating cells in cutaneous malignant melanoma. We also studied the effect of hyperforin on tumor- and endothelial cell growth in vitro and in vivo. The density of lymphocyte subpopulations, macrophages, dendritic cells and CD34 + microvessels was determined by immunohistochemistry in primary tumor samples from 52 patien...

Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin suspended as coarse aggregates in phosphate-buffered saline, with the biodist...

The Evolution of Increased Competitive Ability (EICA) hypothesis predicts that introduced plants should lose enemy resistance and in turn evolve increased size or fecundity. We tested the first prediction of this hypothesis by growing introduced North American and native European genotypes of St. John’s Wort (Hypericum perforatum) in common gardens in the state of Washington, USA, and in Girona...

drying is considered as one of the important stages after plant harvesting which plays an important role in maintaining the quantity and quality of their active ingredients. st. john's wort (hypericum perforatum l.) is an important medicinal plant that high percentages of hypericin in its leaves and flowers are considered as the most important feature of the iranian species. in this resear...