It has been proposed that a single sniff generates a "snapshot" of the olfactory world. However, odor coding on this timescale is poorly understood, and it is not known whether coding is invariant to changes in respiration frequency. We investigated this by recording spike trains from the olfactory bulb in awake, behaving rats. During rapid sniffing, odor inhalation triggered rapid and reliable...

Open-heart surgery with cardiopulmonary bypass (CPB) remains the standard approach for complex cardiac pathologies, such as advanced coronary heart disease and severe valvular defects. Platelet dysfunction has been widely reported, both structural functional changes being elicited by CPB circuit. Succinate is a mitochondrial substrate that metabolized through II (CII) but impermeable to cellula...

Streptolydigin interferes with oxidative phosphorylation in rat liver mitochondria. The agent acts primarily as an uncoupler of respiration-associated phosphorylation but also impairs respiration to various degrees depending on the substrate. Streptolydigin partially inhibits electron flow at a point past the cytochrome b and prior to the cytochrome c reduction site. Streptolydigin also inhibit...

Partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson's disease in rodents. The hypothesis that rotenone enhancement of neuronal cell death is attributable to oxidative stress was tested in an acute glutamate excitotoxicity model using primary cultures of rat cerebellar granule neurons. As little as 5 nM rotenone increased mitochondrial superoxide...

aim and background: enuresis is known as one of the most common disorders in childhood. snoring at night and obstructive sleep apnea have been considered as probable causes, at least in some cases. thus, the importance of a breathing exercise to reduce bedwetting in children with nocturnal snoring should be noted. method and materials: this study is an experimental survey with control group. th...

context studies show that despite the role of mouth care in preventing ventilator-associated pneumonia, there is no high quality evidences for it. this study reviewed the literature related to mouth care in patients receiving mechanical ventilation. evidence acquisition pubmed, ovide, elsevier, proquest, iranmedex, sid, and magiran databases were searched using key terms such as oral care, mout...

Objective(s): This work aimed to assess the effect of 10 new chromon-3-aldehyde derivatives on changes of mitochondrial function under the conditions of brain ischemia in rats. Materials and Methods: The work was executed on BALB/c male-mice (acute toxicity was evaluated) and male Wistar rats, which were used to model cerebral ischemia b...