During early B lymphopoiesis, developing B cells maintain lineage commitment despite the local presence of myeloid lineage-promoting cytokines such as GM-CSF and IL-3. Previous observations suggest that the B cell-specific transcription factor Pax5A (paired box 5A transcription factor) plays a role in maintaining B cell lineage commitment by limiting expansion and survival of early IL-3/GM-CSF-...

Stem cells reside in a particular microenvironment known as a niche. The interaction between extrinsic cues originating from the niche and intrinsic factors in stem cells determines their identity and activity. Maintenance of stem cell identity and stem cell self-renewal are known to be controlled by chromatin factors. Herein, we use the Drosophila adult testis which has two adult stem cell lin...

New SARS-CoV-2 variants emerged in the United Kingdom and South Africa December 2020 concomitant with Brazillian variant February 2021 (B.1.1.248 lineage) currently sparking worldwide during last few months. The new strain 501.V2 bears three mutations spike receptor-binding domain (RBD); K417 N, E484K, N501Y, while Brazilian B.1.1.248 lineage has 12 mutations. In current study, we simulate comp...

Stem cell differentiation is a complex biological event. Our understanding of this process is partly hampered by the co-existence of different cell subpopulations within a given population, which are characterized by different gene expression states driven by different underlying transcriptional regulatory networks (TRNs). Such cellular heterogeneity has been recently explored with the modern s...

The C. elegans cell lineage provides a unique opportunity to look at how cell lineage affects patterns of gene expression. We developed an automatic cell lineage analyzer that converts high-resolution images of worms into a data table showing fluorescence expression with single-cell resolution. We generated expression profiles of 93 genes in 363 specific cells from L1 stage larvae and found tha...

stem cells are self-renewing and undifferentiated cell types that can be differentiate into functional cells. stem cells can be classified into two main types based on their source of origin: embryonic and adult stem cells. stem cells also classified based on the range of differentiation potentials into totipotent, pluripotent, multipotent, and unipotent. multipotent stem cells have the ability...

The fate of a cell may be determined by cell lineage, by interaction between the cell and its environment, or by both. The importance of cell lineage in specifying cell fate varies considerably in the development of different cells. At one extreme, cell lineage may be highly determinate; the fate of a cell can be predicted from its ancestry. At the other extreme, cell lineage may play no role. ...