The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. Several studies have addressed lactic fermentation plus addition of enzymes as a means to degrade gluten in order to prevent adverse response in ce...

Celiac sprue is a disorder characterized by the symptoms of malabsorption and an abnormal small bowel histology, which is due to the patient's intolerance to gluten. Gluten is a protein found in wheat and wheat products. The typical symptoms of malabsorption include weight loss, abdominal distention, bloating, diarrhea and steatorrhea. However, the severity of the disease varies greatly among t...

Celiac disease (CD) is an autoimmune condition, triggered by gluten ingestion, which affects the small intestine, destroying villi. It considered that in recent years CD has undergone a real “metamorphosis” due to constant increase diagnosed cases. The only treatment available for BC stick gluten-free diet throughout your life. Adherence GFD requires strict elimination of gluten-containing prod...

Microscopic enteritis (ME) is characterized by abnormal infiltration of intraepithelial lymphocytes in intestinal mucosa. It was described as duodenal lymphocytosis or lymphocytic duodenitis until the dedicated Consensus Conference of 2015. ME represents a common feature of several gluten-mediated and non-gluten related diseases; therefore, it is an umbrella term embracing several conditions. T...

Celiac disease is a complex polygenic systemic disorder caused by dietary gluten exposure that selectively occurs in genetically susceptible people. The potential celiac defined the presence of disease-specific antibodies and compatible human leukocyte antigen but without histological abnormalities duodenal biopsies. At present, only treatment lifelong adherence to gluten-free diet. Despite its...

Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals, including rye and barley that are generally introduced in the infant's diet at weaning. At present, two schools of thought claim that changing early feeding regimens in at-risk infants can either prevent the onset...

CONTEXT The ingestion of gluten is responsible for the symptoms of Celiac disease, but other environmental factors can also influence. Strains of the Bifidobacterium genus have been shown to afford protection against the inflammatory response and mucosal damage caused by gliadin peptides in vitro. OBJECTIVES This study was designed to compare the concentration of fecal bifidobacteria and pH o...

Celiac disease is an autoimmune disorder, caused by a permanent intolerance to gluten contained in wheat and to similar prolamines present in barley and rye. It is a common disease as its prevalence, in Caucasian populations, is about 1%. There are several patterns of clinical presentation: typical (with gastrointestinal symptoms), atypical (extraintestinal manifestations), and silent forms, al...

BACKGROUND The involvement of the peripheral nervous system in children with celiac disease is rare. CASE CHARACTERISTICS A 15- year- old girl affected by celiac disease, who presented with an acute polyneuropathy after accidental reintroduction of gluten in her diet. OBSERVATION Neurological examination suggested asymmetric weakness of both legs distally. Anti-tissue transglutaminase antib...