Cecal crypts represent a unique niche that are normally occupied by the commensal microbiota. Due to their density and close proximity to stem cells, microbiota within cecal crypts may modulate epithelial regeneration. Here we demonstrate that surgical stress, a process that invariably involves a short period of starvation, antibiotic exposure, and tissue injury, results in cecal crypt evacuati...

1 Patients and animals with chronic kidney disease (CKD) exhibit profound alterations in 2 the gut environment including shifts in microbial composition, increased fecal pH, and increased 3 blood levels of gut microbe-derived metabolites (xeno-metabolites). The fermentable dietary 4 fiber—high amylose maize resistant starch type 2 (HAMRS2)—has been shown to alter the gut 5 milieu, and in CKD ra...

BACKGROUND AND STUDY AIMS No studies have looked at the quality of cecal images versus the outcomes of colonoscopic procedures. Here, we tested our hypothesis that endoscopists who provide better image documentation of the cecum during their procedures have a higher polyp detection rate (PDR). PATIENTS AND METHODS In this retrospective study, planned colonoscopies performed by 16 experienced ...

Human sepsis is characterized by a set of systemic reactions in response to intensive and massive infection that failed to be locally contained by the host. Currently, sepsis ranks among the top ten causes of mortality in the USA intensive care units. During sepsis there are two established haemodynamic phases that may overlap. The initial phase (hyperdynamic) is defined as a massive production...

The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...

Abstract The main objective of this study was to prepare colon-specific pellets of budesonide using pectin as film coating.  Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH o...