The paper presents preliminary results on the impact of two link scheduling algorithms on CDV (Cell Delay Variation). The traditional FIFO queueing is compared with two versions of the Virtual Spacing algorithm proposed by Roberts in 12, 13]. The intercell time distribution and the 1-point CDV imposed on a CBR traac are investigated. The simulation connguration is a queueing model for a sequenc...

The potential of immune-stimulating complexes (iscoms), a novel form of antigenic presentation, for the induction of protective immunity against morbillivirus infection was shown by immunizing dogs with canine distemper virus (CDV) iscoms, which contained the fusion (F) protein and a minor amount of the haemagglutinin of the virus. The immunized dogs developed CDV-neutralizing antibodies but, i...

Sequence analysis of the haemagglutinin protein (H) gene of the morbillivirus (PDV-2) isolated from a Siberian seal (Phoca sibirica) during the 1987/1988 epizootic in Lake Baikal revealed that it was most closely related to two recent isolates of canine distemper virus (CDV) from Germany and different from CDV vaccines currently in use in that region. The virus continued to circulate in seals i...

Enhanced canine distemper virus (CDV) nucleoprotein RNA was applied to paraffinembedded tissues from dogs with spontaneous CDV infections. In addition to proteinase K, the tissues were autoclaved in various solutions as a pre-treatment (Trilogy, TBS S3006, H-3301, and S1700) and then compared. The in situ hybridization (ISH) intensity was assessed using integrated optical density (IOD) and tiss...

canine distemper virus (cdv) is the cause of canine distemper (cd) which is a severe and highly contagious disease in dogs. in the present study, a duplex reverse transcription polymerase chain reaction (rt-pcr) method was developed for the detection and differentiation of wild-type and vaccine strains of cdv. four primers were designed to detect and discriminate the two viruses by generating 6...

Between 2001 and 2003, a total of 194 samples of brain tissues of wild mustelids from the Czech Republic were tested for the presence of canine distemper virus (CDV) by direct immunofluorescence examination. Out of 21 animals exhibiting symptoms of the disease or changed behaviour, one mustelid was CDV positive (5% prevalence). In this group, 1 out of 18 stone martens (Martes foina) was CDV pos...

Studies comparing canine distemper virus (CDV) strains from Africa with that of previously described lineages have been hampered due to a lack of field strains for in vitro experiments. Since the attenuation of the Onderstepoort strain in the 1940s, there have not been any reports of CDV isolations in southern Africa. Clinical specimens consisting of whole blood, spleen, lungs, brain and cerebr...

Domestic dogs are common amongst communities in sub-Saharan Africa and may serve as important reservoirs for infectious agents that may cause diseases in wildlife. Two agents of concern are canine parvovirus (CPV) and canine distemper virus (CDV), which may infect and cause disease in large carnivore species such as African wild dogs and African lions, respectively. The impact of domestic dogs ...

Inverse correlations between genetic variability and parasitism are important concerns for conservation biologists. We examined correlations between neutral genetic variability and the presence of antibodies to canine distemper virus (CDV) and feline parvovirus (FPV) in a free-ranging population of raccoons. Over 3 years there was a strong relationship between age and seroprevalence rates. Most...

Canine distemper virus (CDV) is a contagious and multisystemic viral disease that affects domestic and wild canines as well as other terrestrial and aquatic carnivores. The disease in dogs is often fatal and no specific antiviral therapy is currently available. In this study, we evaluated the in vitro antiviral activity against CDV of proanthocyanidin A2 (PA2), a phenolic dimer belonging to the...