creased clearance of the sialic aciddeficient transferrin isoforms (CDT) via the asialoglycoprotein receptor. The underlying mechanism for the increased CDT in our patient might be different from that in viral liver cirrhosis. To explore the etiology of this finding, measurements of neuraminidase and sialyltransferase activity (9 ) and of the sialyltransferase mRNA concentration (10 ) may be us...

I discuss algorithms for constructing constrained Delaunay triangulations (CDTs) in dimensions higher than two. If the CDT of a set of vertices and constraining simplices exists, it can be constructed in O(nvns) time, where nv is the number of input vertices and ns is the number of output d-simplices. The CDT of a starshaped polytope can be constructed in O(ns log nv) time, yielding an efficien...

Multiplex SNP discrimination in the multiple codons of the genomic DNA is demonstrated by applying controller DNA technology (CDT) to MDR-TB 9G DNAChips. CDT allowed the efficient detection of 20 SNPs in five codons of the genomic DNA in 40 min. CDT could distinguish SNP targets to as low as 1 copy of the genomic DNA. 100% agreement with the sequencing analysis of clinical samples highlighted t...

We hypothesized that, in the absence of clinically recognized dementia, cognitive dysfunction measured by the clock draw test (CDT) is associated with greater functional impairment in men and women with peripheral artery disease (PAD). Participants were men and women aged 60 years and older with Mini-Mental Status Examination scores ≥ 24 with PAD (n = 335) and without PAD (n = 234). We evaluate...

Alcohol use and abuse is a major social and economic problem in many societies. Carbohydrate-deficient transferrin (CDT) is a widely used and highly specific biochemical alcohol marker of prolonged alcohol abuse. Increased knowledge about the clinical characteristics of CDT may lead to better possibilities of employing CDT as a biochemical alcohol marker of risky and heavy alcohol consumption a...

This paper has two main objectives. The first is to provide an overview of the CDT annotation design with special emphasis on the modeling of the interface between syntactic and morphological structure. Against this background, the second objective is to explain the basic fundamentals of how CDT is marked-up with semantic relations in accordance with the dependency principles governing the anno...

Several environmental factors regulate the expression of virulence genes under certain conditions and the expression of bacterial virulence determinants. Cytolethal distending toxin (CDT) is an important virulence determinant secreted by Campylobacter jejuni (C. jejuni), a leading cause of gastrointestinal bacterial pathogen worldwide. Therefore, the aim of the study was to investigate the effe...

AIMS To test the hypotheses that performance on a clock-drawing task (CDT) diminishes over time and that poor performance is associated with development of dementia and reduced survival. METHODS Participants in the population-based Leisure World Cohort Study were asked to complete a CDT in follow-up questionnaires mailed in 1992 and 1998. Dementia status was determined using in-person evaluat...

Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometimes covering different transferrin glycoforms, has complicated the comparability...

In the diagnosis of alcohol abuse transferrin (Tf) allelic D variants generate false-positive test results for carbohydrate-deficient transferrin (CDT) as assessed by their electrophoretic migration patterns. The predominant Tf C1 allele encodes a protein for which the most prevalent isoform has a pI of 5.4, i.e., four sialic acids and two bound ion molecules. Carriers of allele D encode Tfs wi...