نتایج جستجو برای: cd26
تعداد نتایج: 686 فیلتر نتایج به سال:
BACKGROUND Interferon and ribavirin therapy for chronic hepatitis C virus (HCV) infection yields sustained virological response (SVR) rates of 50-80%. Several factors such as non-1 genotype, beneficial IL28B genetic variants, low baseline IP-10, and the functionality of HCV-specific T cells predict SVR. With the pending introduction of new therapies for HCV entailing very rapid clearance of pla...
b-thalassemia là một bệnh rối loạn di truyền lặn do đột biến gen HBB nằm trên cánh ngắn nhiễm sắc thể số 11 gây suy giảm tổng hợp chuỗi b-globin. Mỗi năm có khoảng 60.000 – 70.000 trẻ em sinh ra bị toàn thế giới trong đó Việt Nam. Trên 350 đã được công bố. Phát hiện người lành mang vai trò quan trọng tư vấn truyền, chẩn đoán trước và tiền làm tổ nhằm tỉ lệ bệnh. Nghiên cứu thực với mục tiêu “xá...
Abstract Background: Lupus is one of the most common autoimmune diseases. IFN-α as an important factor in the pathogenesis of lupus has been introduced. Also, CD26 with its enzymatic activity has many roles in the regulation of immune responses. In the current study, we investigated the level of CD26 and IFN-α in the serum of SLE patients. Materials and methods: In this case-control study, 46 S...
Hematopoietic stem cells (HSCs) are responsible for maintaining all blood cells throughout the lifetime of an individual, and are used clinically to treat various malignant and nonmalignant disorders. However, for some HSC grafts, for instance from umbilical cord blood (UCB), limited numbers of HSCs restrict their application to pediatric patients. Expanding HSCs in vitro or improving their hom...
Tumor initiating cells (TIC) are increasingly being put forward as a potential target for intervention within colorectal cancer. Whilst characterisation and outgrowth of these cells has been extensively undertaken in primary colorectal cancers, few data are available describing characteristics within the metastatic setting. Tissue was obtained from patients undergoing surgical resection for col...
The conformations of some 'giant' cyclodextrins (CDn, n = 40, 70, 85, 100) were examined by molecular dynamic simulations using the Glycam06 force field. CD14 and CD26, the largest cyclodextrins, for which crystallographic data are available, were also studied as reference structures. Principal component analysis was used for the analyses of the simulation trajectories. In cases where band-flip...
Directional migration determines hematopoietic stem/progenitor cell (HSPC) homing, which depends upon the interaction between the chemokine CXCL12 and its receptor CXCR4. CD26 is a widely expressed membrane-bound ectopeptidase that cleaves CXCL12 thereby depleting its chemokine activity. We identified tissue-factor pathway inhibitor (TFPI) as a biological inhibitor of CD26 in murine and human H...
Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to define the heterogeneity within the LSC population in chronic phase chronic myel...
CD26 is a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but whose natural substrates and immunological functions have not been clearly defined. Several chemo-kines, including RANTES (regulated on activation, normal T cell expressed and secreted), have now been shown to be substrates for recombinant soluble human CD26. The truncated RANTES(3-68) lacked the ability o...
Alterations in dipeptidyl peptidase-IV (DPP-IV) enzymatic activity are characteristic of malignant transformation. Through its well-characterized functionality in regulating the activity of bioactive peptides by removal of the N-terminal dipeptide, DPP-IV activity may have profound effects upon metastatic potential and cell growth. Although DPP-IV/CD26 (EC 3.4.14.5) is the canonical representat...
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