Herbs are known to play a vital role in the management of various liver diseases. Garlic oil (GO) contains numerous organosulfur compounds with potential hepatoprotective effects. The present work was planned to evaluate the possible preventive role of GO on biochemical and histopathological alterations induced by combined administration of ethanol (EOH) and carbon tetrachloride (CCl4) in rat l...

Protective action of Ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4). Male albino mice were divided into six groups. group I was normal control group; group II received olive oil (CCl4 solvent), groups III-VI received CCl4. After inducing hepatic damage, group III served as control for CCl4; a...

Protective action of Ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4). Male albino mice were divided into six groups. group I was normal control group; group II received olive oil (CCl4 solvent), groups III-VI received CCl4. After inducing hepatic damage, group III served as control for CCl4; a...

Nghiên cứu được tiến hành với mục tiêu đánh giá độc tính cấp và tác dụng bảo vệ gan của cao cồn vỏ thân Núc nác. sử phương pháp Litchfield – Wilcoxon để xác định đường uống giảm trên mô hình gây bằng carbon tetraclorid (CCl4). Kết quả nghiên cho thấy không LD₅₀ chiết Sau 8 ngày uống, nác liều 300 mg/kg 900 thể hiện thông qua việc làm nồng độ AST, ALT, MDA, ngoài ra hạn chế tổn thương bởi CCl4 c...

Background & Aim: Bombax costatum stem bark is traditionally used in treatment of liver diseases but the anti-hepatofibrotic effect of its ethyl acetate fraction has not been scientifically evaluated. This study aimed to evaluate the anti-hepatofibrotic effect of ethyl acetate fraction of B. costatum stem bark (EAB) against carbon tetrachloride (CCl4) induced liver fibrosis in mice. Experimenta...

Herbs are known to play a vital role in the management of various liver diseases. Thymoquinone (TQ) is the bioactive constituent of Nigella sativa seed. The present work was planned to evaluate the potential hepatoprotective effects of TQ against the cytotoxic effects and the oxidative stress induced by carbon tetrachloride (CCl4) in isolated primary rat hepatocytes. Cytotoxicity was determined...

We study the temperature dependence of the heat capacity Cp for the pure CH4 and the coadsorbed CH4/CCl4 on graphite near the melting point. The heat capacity peaks are analyzed using the experimental data from the literature by means of the power-law formula. The critical exponents for the heat capacity are deduced below and above the melting point for CH4 (T = m 104.8 K) and CH4/CCl4 (T = m 9...

The aim of this study was to investigate the role of Mesenchymal Stem Cell (MSC) conditioned medium (CM(MSC)) on apoptosis of cultured mouse primary hepatocytes after in vivo carbon tetrachloride (CCl4)-induced acute liver injury. The acute liver injury was induced by injecting CCl4 intraperitoneally in C57/BL6 mice. Hepatocytes were isolated by liver perfusion, cultured in a defined medium to ...

BACKGROUND Carbon tetrachloride (CCl4) is a potent nephrotoxin, as it causes acute as well as chronic toxicity in kidneys. Therefore, this study was carried out to assess the pharmacological potential of different fractions of Carissa opaca fruits on CCl4-induced oxidative trauma in the kidney. METHODS The parameters studied in this respect were the kidney function tests viz, serum profile, u...

This study was undertaken to investigate the protective effect of Liv.52, a herbal formulation, on various serum and liver marker enzymes, lipid peroxidation and histological changes in the liver of male albino rats suffering long-term carbon tetrachloride (CCl4) poisoning. It was observed that the activities of serum marker enzymes, hepatic enzymes and NADPH-dependent lipid peroxidation were s...