Gap junctions form intercellular channels that mediate metabolic and electrical signaling between neighboring cells in a tissue. Lack of an atomic resolution structure of the gap junction has made it difficult to identify interactions that stabilize its transmembrane domain. Using a recently computed model of this domain, which specifies the locations of each amino acid, we postulated the exist...

Highly penetrant cancer syndromes account for less than 5% of all cases with familial colorectal cancer (CRC), and other genetic contribution explains the majority of the genetic contribution to CRC. A CRC susceptibility locus on chromosome 9q has been suggested. In this study, families where risk of CRC was linked to the region, were used to search for predisposing mutations in all genes in th...

PURPOSE Days supply (prescription duration) values are commonly used to estimate drug exposure and quantify adherence to therapy, yet accuracy is not routinely assessed, and potential inaccurate reporting has been previously identified. We examined the impact of cleaning days supply values on the measurement of adherence to oral bisphosphonates. METHODS We identified new users of oral bisphos...

We present the first rigorous examples of non-singular Hubbard models which exhibit ferromagnetism at zero temperature. The models are defined in arbitrary dimensions, and are characterized by finite-ranged hoppings, dispersive bands, and finite on-site Coulomb interaction U . The picture, which goes back to Heisenberg, that sufficiently large Coulomb interaction can revert Pauli paramagnetism ...

if a real solution a∗ for a∗ + V (a∗) = 0 (3) exists and g(t) starts from an appropriate neighborhood of a∗. The leading term is universal in the sense that an initial data does not appear in this term. The purpose of this work is (i) to find a condition that the next-to-leading term be also universal when F ̸= 0. and (ii) to explicitly derive the subleading term when (i) satisfies. This is phys...

Occupational regulations are developed to conserve the hearing of a worker noise-exposed for 8 h per day. Workers often work longer shifts. In order to account for longer exposures, regulators have adopted variations of the equal energy hypothesis in which the ear is modeled as an integrator of acoustic energy over time. Thus time and energy can be traded to produce equal hearing loss. This res...

CONTEXT Noise of machines in various agro-based industries was found to be the major occupational hazard for the workers of industries. The predominant noise sources need to be identified and the causes of high noise need to be studied to undertake the appropriate measures to reduce the noise level in one of the major agro-based industries, oil mills. AIMS To identify the predominant noise so...

The most prevalent disease-causing mutation of CFTR is the deletion of Phe508 (ΔF508), which leads to defects in conventional Golgi-mediated exocytosis and cell surface expression. We report that ΔF508-CFTR surface expression can be rescued in vitro and in vivo by directing it to an unconventional GRASP-dependent secretion pathway. An integrated molecular and physiological analysis indicates th...

Jejunojejunal intussusception and jejunojejunal lipomas are both very rare clinical entities. The present case report describes this event in an adult patient with severe episodes of hematochezia and colicky upper abdominal pain. The diagnosis was not made preoperatively, as none of the endoscopic findings were pathognomonic and, furthermore, CT scans could not rule out malignancy. Exploratory ...

BACKGROUND Congenital myopathies due to ryanodine receptor (RYR1) mutations are increasingly identified and correlate with a wide range of phenotypes, most commonly that of malignant hyperthermia susceptibility and central cores on muscle biopsy with rare reports of distal muscle weakness, but in the setting of early onset global weakness. METHODS We report a case of a patient presenting with...