In this study, the noncovalent functionalization of graphene with cationic porphyrins in an aqueous medium was investigated using UV-vis and fluorescence approaches. To characterize the interaction between graphene and cationic porphyrins, 5,10,15,20-tetra (4-pyridyl)-21H,23H-porphine, 5,10,15,20-tetrakis (1-methyl-4-pyridinio) porphyrin tetra (p-toluenesulfonate) and 5,10,15,20-tetrakis (4-tri...

Previously, we developed a novel siRNA transfer method to the liver by sequential intravenous injection of poly-L-glutamic acid (PGA) and cationic liposome/siRNA complex (cationic lipoplex). In this study, we examined the effects of the charge ratio (+/−) of cationic liposome/siRNA, molecular weight of PGA and cationic lipid of cationic liposome on the biodistribution of siRNA after sequential ...

We present here the first report of a metalloporphyrin-based antioxidant that can prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an autoimmune process whereby T-cells recognize pancreatic beta-cell antigens and initiate a leukocyte infiltrate that produces proinflammatory cytokines and reactive oxygen species (ROS), ultimately leading to beta-cell destruction. Because isl...

Cationic materials exhibit remarkable anti-inflammatory activity in experimental arthritis models. Our aim was to confirm this character of cationic materials and investigate its possible mechanism. Adjuvant-induced arthritis (AIA) models were used to test cationic materials for their anti-inflammatory activity. Cationic dextran (C-dextran) with different cationic degrees was used to investigat...

The current commercial application of ink-jet reactive inks to cotton fabrics has been through pre-treating with pad liquor prior to printing. In This study made an effort to provide a single phase ink-jet printing process for printing cotton fabric using the novel cationic reactive dye in ink’s formulation. Cotton fabric was printed upon with the novel cationic reactive dye and commercial anio...

Cationic lipids constitute a family of synthetic vectors commonly used for nucleic acids delivery. We herein report the results of a systematic study that aimed to compare the transfection efficacies of cationic lipophosphoramidates possessing either two identical lipid chains (termed symmetric cationic lipids) or two different lipid chains (non-symmetric cationic lipids). In addition, we also ...

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro com...

The electronic structure and photophysical properties of (C=C)TTP(2+) (TTP = tetra-p-tolylporphyrin) were scrutinized by using quantum mechanical calculations and transient absorption spectroscopic measurements. When compared to a metalloporphyrin, the presence of the C=C unit in (C=C)TTP(2+) causes a splitting of the degenerate LUMO and a large decrease in the HOMO-LUMO gap, while the 2+ charg...

In this work we show that it is possible to prepare and study a cobalt-substituted hemoglobin-a coboglobin (Cb).-and that this reconstituted metalloprotein exhibits reversible oxygen binding. The effect of the protein environment on Co(II)-protoporphyrin IX is directly observed by esr measurements on deoxy- and oxy-Cb and by oxygen uptake measurements, all of which may be compared with similar ...