The impact of acid deposition and tree harvesting on three lakes and their representative sub-catchments in the Muskoka-Haliburton region of south-central Ontario was assessed using a critical loads approach. As nitrogen dynamics in forest soils are complex and poorly understood, for simplicity and to allow comparison among lakes and their catchments, CLs (A) for both lakes and forest soils wer...

OBJECTIVE To evaluate the efficiency of resources allocation and sustainability of the use of netupitant+palonosetron (NEPA) for chemotherapy-induced nausea and vomiting (CINV) prophylaxis assuming the Italian National Health Service (NHS) perspective. A published Markov model was adapted to assess the incremental cost-utility ratio of NEPA compared with aprepitant (APR) + palonosetron (PALO), ...

Retinoids exhibit chemotherapeutic and chemopreventive activities, possibly due to their ability to modulate cell growth, differentiation, and apoptosis. These effects are thought to be mediated by nuclear retinoic acid (RA) receptors (RARs) and retinoid X receptors, each of which includes three subtypes (alpha, beta, and gamma) that act as transcription factors. To determine whether RARs play ...

Witness tree data from the southeastern United States (lat 33◦30′ N, long 86◦30′W) were analyzed using catchment and distance analysis to quantify the effects of Native American settlement on the composition of forest trees. Thirty Creek Indian villages comprising 18 settlement catchments were included in the sample, which is the largest Native American–forest interaction study using witness tr...

PURPOSE EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome. Here, we use an antibody drug conjugate (MEDI-547) composed of a fully human monoclonal antibody against both human and murine EphA2 (1C1) and the tubulin polymerization inhibitor monomethylauristatin F. EXPERIMENTAL DESIGN EphA2 expression was examined in endometrial cancer ...

Scientific high-end computing (HEC) has become an important tool for scientists world-wide to understand problems, such as in nuclear fusion, human genomics and nanotechnology. Every year, new HEC systems emerge on the market with better performance and higher scale. With only very few exceptions, the overall availability of recently installed systems has been lower in comparison to the same de...

Human-elephant conflict (HEC) threatens the survival of endangered Asian elephants (Elephas maximus). Translocating "problem-elephants" is an important HEC mitigation and elephant conservation strategy across elephant range, with hundreds translocated annually. In the first comprehensive assessment of elephant translocation, we monitored 16 translocations in Sri Lanka with GPS collars. All tran...

The role, effectiveness, and even existence of hospital ethics committees (HECs) are not universally agreed upon. Over the past 20 years, the study of HECs has focused mainly on their structure, scope, and function, making the results more descriptive than anything. In an effort to present study results that could help HECs better serve the needs of their organizations, the authors of this arti...

Floods are one of the deadliest natural hazards and exacerbated by changes in land-use climate. Urban development decreases infiltration reducing pervious areas increases accumulation pollutants during dry weather. It also periods. During rainy events, there is an increase pollution concentrations runoff that may be a source water supply drought Modeling quantity quality dynamics stormwater req...