BACKGROUND Aging is associated with the loss of endocrine function. In this study, Vitex agnus-castus (Vitex), which has antioxidant effects and high levels of phytoestrogen, was investigated with regard to the hypothalamic-pituitary-gonadal axis and antioxidant indices in natural aging and in a d-galactose induced aging model in female mice. METHODS The mice were subcutaneously injected with...

OBJECTIVE In this study, we aimed at evaluation of the efficacy of Hypericum perforatum and flaxseed on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women. MATERIALS AND METHODS We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials (RCT) to explore trials that assessed the effectiveness of H. perforatum and flaxseed on hot flash, vagina...

An extract from ripe fruit of Vitex agnus-castus (Vitex) has been used to treat patients with various obstetric and gynecological disorders in Europe. We have demonstrated that Vitex showed cytocidal effects on various types of cancer cell lines including a human colon carcinoma cell line, COLO 201. In this study, we extended our previous study to investigate the detailed mechanisms underlying ...

The aim of the present study was to evaluate the effect of a hydro-alcoholic extract of Vitex agnus-castus (VAC) fruit on blood urea nitrogen (BUN), creatinine (Cr) and, kidney histology of a female mouse model of D-galactose induced aging. In this experimental study, 72 NMRI mice were divided into 6 groups: control, VAC, D-galactose, D-galactose+VAC, aging, and aging+VAC. D-galactose was injec...

This study was conducted to determine the Protective effect of aqueous extracts Vitex agnus castus plant both doses, Normal active does(50mg/kg) and double (100mg/kg) in liver enzymes comported deferent it between male female’s Mice, that exposed oxidative stress induced by hydrogen peroxide (0.5%) with drinking water for (30) days, there were distributed into 10 groups which are (control group...

Given the ecological and epidemiological specialization of Hyalesthes obsoletus, principle vector ‘Candidatus Phytoplasma solani’, primary objective this study was to develop molecular tools for discriminating three host plant associations populations: (i) Convolvulus arvensis–Urtica dioica (Ca–Ud), (ii) Vitex agnus-castus (Vac), (iii) Crepis foetida (Cf). The genetic diversity nearly full-leng...