A 40-year-old male presented with a history of low-grade fever, weight loss, night sweats and breathlessness of 3 months duration. On examination, the patient had freely mobile lump in left lumbar region. The lump was surgically excised. Histological examination and immunohistochemistry of the specimen were consistent with the diagnosis of plasma cell variant of the Castleman disease. The patie...

Le syndrome TAFRO est un inflammatoire systémique proche de la maladie Castleman, associant, anasarque, fièvre, insuffisance rénale et/ou fibrose réticulinique et organomégalie. Nous rapportons première observation vascularite nécrosante compliquant TAFRO. Une femme 69 ans présentait amaigrissement, splénomégalie, adénomégalies, oligoanurie livedo nécrotique extensif au décours d’une diarrhée a...

Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) is a serious, uncommon disease that occurs in patients who are positive for HIV and human herpesvirus-8 (HHV-8). It characterized by constellation of clinical findings, including fever, weight loss, fluid retention, as well lack multicentric Castleman (MCD) features on histopathology an elevated serum HHV-8 viral load. Diagnosis often delayed...

Disease overview POEMS syndrome is a paraneoplastic due to an underlying plasma cell neoplasm. The major criteria for the are polyradiculoneuropathy, clonal disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume over...

Six personally observed cases of this lesion are reported and the literature is reviewed. One hundred and thirty-four cases have been reported to date. The lesion has occurred in many sites, but is commonest in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%). Ninety per cent of cases are symptomless or have only the pressure symptoms, 10% have systemic signs, namely, fever, raised ...