نتایج جستجو برای: caspase3 gene

تعداد نتایج: 1141611  

2017
Xueqin Wang Xuemei He Xian Deng Yanzheng He Xiangyu Zhou

Oxidative stress is implicated in the pathophysiology of vascular diseases, including atherosclerosis, aneurysm and arteriovenous fistula. A previous study from our lab suggested that microRNA (miR)‑4463 may be involved in the pathogenesis of vascular disease; however, the roles of oxidative stress in the molecular mechanisms underlying the actions of miR‑4463 in vascular disease have yet to be...

2017
Xiaoyao Ma Yuan Zhang Zengyong Wang Yunbing Shen Man Zhang Quandeng Nie Yuanyuan Hou Gang Bai

SCOPE Ursolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal transduction processes linked to the anti-inflammation pathway have not been thoroughly elucidated to d...

2017
Jing Zhang Yang Wang Ye Zhou Qing-Yu He

Colorectal carcinoma (CRC) remains one of the leading causes of death in cancer-related diseases. In this study, we aimed to investigate the anticancer effect of Jolkinolide B (JB), a bioactive diterpenoid component isolated from the dried roots of Euphorbia fischeriana Steud, on CRC cells and its underlying mechanisms. We found that JB suppressed the cell viability and colony formation of CRC ...

2014
Jiujiao Gao Qiu Yan Shuai Liu Xuesong Yang

Resistance to fluoropyrimidine-based chemotherapy is the main reason for the failure of cancer treatment, and drug resistance is associated with an inability of tumor cells to undergo apoptosis in response to treatment. Alterations in the expression of epithelial cell adhesion molecule (EpCAM) affect the sensitivity or resistance of tumor cells to anticancer treatment and the activity of intrac...

2016
Xuan Li Yan-Kui Wang Zhi-Qiang Song Zhi-Qiang Du Cai-Xia Yang

Meiotic maturation of mammalian oocytes is a precisely orchestrated and complex process. Dimethyl sulfoxide (DMSO), a widely used solvent, drug, and cryoprotectant, is capable of disturbing asymmetric cytokinesis of oocyte meiosis in mice. However, in pigs, DMSO's effect on oocyte meiosis still remains unknown. We aimed to evaluate if DMSO treatment will affect porcine oocyte meiosis and the un...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Andrea Miccoli Giorgia Gioacchini Francesca Maradonna Francesca Benato Tatjana Skobo Oliana Carnevali

BACKGROUND/AIMS Probiotic strains have been recognized to exert important roles in many biological systems, including immune response, growth, development and reproduction. However, to date, no studies have focused either on the relation among probiotics and maternal factors or on probiotics' ability to qualitatively and/or quantitatively modulate maternal transcripts. METHODS In this study, ...

2017
Fuhao Qiao Jian Fang Jinfeng Xu Wenqiu Zhao Ying Ni Bufugdi Andreas Akuo Wei Zhang Yun Liu Fangfang Ding Guanlin Li Baoguo Liu Hua Wang Shihe Shao

Adrenomedullin has been shown to be overexpressed in many tumors, including gastric cancer tumors; however, its mechanism of action remains unclear. In this study, we examined the role of adrenomedullin in the pathogenesis of gastric cancer. Using clinical specimens and immunohistochemistry, we found that the expression levels of adrenomedullin and its receptors are inordinately elevated as com...

2016
Yajie Zhang Wenxia Xu Pan Ni Aiping Li Jianwei Zhou Shan Xu

Cisplatin is the first-line agent utilized for the clinical treatment of a wide variety of solid tumors including gastric cancer. However, the intrinsic or acquired cisplatin resistance is often occurred in patients with gastric cancer and resulted in failure of cisplatin therapy. In order to investigate if miRNA involves in cisplatin resistance of human gastric cancer, we first screened and co...

2014
Jingwen Si Ning Wang Huan Wang Juan Xie Jian Yang Hui Yi Zixuan Shi Jing Ma Wen Wang Lifang Yang Shiqiang Yu Junchang Li Meijing Wang

In this study, we evaluated the effect of astragaloside IV (Ast IV) post-ischemia treatment on myocardial ischemia-reperfusion (IR) injury (IRI). We also examined whether hypoxia inducible factor-1α (HIF-1α) and its downstream gene-inducible nitric oxide (NO) synthase (iNOS) play roles in the cardioprotective effect of Ast IV. Cultured cardiomyocytes and perfused isolated rat hearts were expose...

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