نتایج جستجو برای: carotid intima
تعداد نتایج: 53144 فیلتر نتایج به سال:
BACKGROUND Shear stress gradients and inflammation have been causally associated with atherosclerosis development in carotid bifurcation regions. The mechanism underlying higher levels of carotid intima-media thickness observed among HIV-infected individuals remains unknown. METHODS AND RESULTS We measured carotid intima-media thickness progression and development of plaque in the common caro...
background: a precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques , which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. we developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to charac...
Thromboxane prostaglandin receptors (TPRs) are deeply involved in the atherosclerotic process whether they are located on platelets, immune cells (monocytes/macrophages or lymphocytes), or vascular cells (smooth muscle cells, endothelial cells). Animal experiments suggested that the inhibition of TPRs has a broad action on atherosclerosis, that is, decrease in atherosclerotic plaque formation a...
BACKGROUND Echogenicity is an ultrasound measure that reflects arterial wall composition. In adult populations, lower carotid intima-media echogenicity relates to an unfavorable cardiovascular risk burden yet appears to reflect a different aspect of arterial wall remodeling than carotid intima-media thickness (CIMT). Since studies on carotid intima-media echogenicity earlier in life are lacking...
BACKGROUND Shoulder pain is a common health problem. The purpose of this study was to assess the associations of lifestyle factors, metabolic factors and carotid intima-media thickness with shoulder pain and chronic (> 3 months) rotator cuff tendinitis. METHODS In this cross-sectional study, the target population consisted of subjects aged 30 years or older participating in a national Finnish...
BACKGROUND AND PURPOSE Angiotensin receptor blocker (ARB)-based treatment reduces cardiovascular events and stroke more than does beta-blocker-based treatment despite similar blood pressure (BP) reduction. We investigated whether these treatments have different effects on cardiac and large-artery remodelling and evaluated the relation of arterial remodelling to hemodynamic changes in subjects w...
Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness.
BACKGROUND AND PURPOSE Carotid intima-media thickness is a marker for subclinical atherosclerosis that predicts subsequent clinical cardiovascular events. The aim of this study was to identify chromosomal loci with linkage or association to common carotid intima-media thickness. METHODS Nuclear families were recruited using the single parental proband sib-pair design. Genotype data were avail...
OBJECTIVE Postprandial hyperglycemia observed in type 2 diabetes mellitus is a risk factor for atherosclerosis. The aim of this study was to investigate the effect of strict glycemic control by nateglinide on common carotid far wall intima-media thickness in type 2 diabetic patients who were already under good glycemic control. METHODS AND RESULTS We performed an open labeled randomized prosp...
It has previously been shown that the degree of shear stress (SS) in the carotid artery is related to both plaque occurrence and intima-media thickness (IMT). Since the echogenecity also is an important feature of plaques, we investigated if a reduced shear stress also is related to the echolucency of plaque and the intima-media complex. In the Prospective Study of the Vasculature in Uppsala Se...
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