A trimethylated amino acid roughly similar in structure to choline, carnitine is a cofactor required for transformation of free long-chain fatty acids into acylcarnitines, and for their subsequent transport into the mitochondrial matrix, where they undergo beta-oxidation for cellular energy production. Mitochondrial fatty acid oxidation is the primary fuel source in heart and skeletal muscle, p...

Abstract Primary carnitine deficiency (PCD) can be lethal. Carnitine is essential for the transfer of long‐chain fatty acids across inner mitochondrial membrane β‐oxidation. The reported prevalence PCD in Faroe Islands 1:300 highest world. Faroese patient cohort has been closely monitored and we now report results from a 10‐year follow‐up study 139 patients. Four patients have died natural caus...

A total of 1,833 mixed-sex growing-finishing pigs (PIC, 337 × 1050; initially 58.5 ± 1.62 lb) were used in a 112-d growth trial to determine the effects adding L-Carnitine throughout entire grow-finishing period or for just last 28 d before marketing on performance and carcass characteristics. There 26 replicate pens per treatment 20 (group 1) 27 2) pen completely randomized design. three diets...

background: metabolic derangements in type 2 diabetes mellitus (t2dm) are likely to affect skeletal muscle contractile functions adversely. levo-carnitine improves muscle contractile functions in healthy humans and rats and corrects metabolic derangements in t2dm. therefore, it is likely to improve muscle contractile functions in t2dm as well. this study was designed to determine the effect of ...

Objectives: Inflammation is a common complication in patients treated with hemodialysis and increasing in inflammatory factors such as C-reactive Protein (CRP) is associated with increased cardiovascular disease and mortality in these patients. The purpose of this study was to investigate the effect of oral L- carnitine supplementation on serum CRP concentration and fasting blood sugar (FBS) in...