In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that c...

Introduction Juvenile idiopathic arthritis (JIA) effects bone health, muscle strength, physical fitness and well-being in children and adolescent. Due to biological medical treatment there is increased outcome of the disease with less flares and arthritis. Impaired bone health, muscle strength and decreased well-being have been reported in this group. There is evidence for intervention studies ...

OBJECTIVE Physical fitness is inversely related to mortality in the general population and in subjects with type 2 diabetes. Here, we present data concerning the relationship between changes in physical fitness and modifiable cardiovascular risk factors in subjects with type 2 diabetes from the Italian Diabetes and Exercise Study. RESEARCH DESIGN AND METHODS Sedentary patients with type 2 dia...

African American (AA) women have an elevated risk of cardiovascular disease and have been reported to have lower cardiorespiratory fitness (CRF) compared with Caucasian American (CA) women. However, little data exist that evaluate racial differences in the change in CRF following aerobic exercise training. CA (n = 264) and AA (n = 122) postmenopausal women from the Dose-Response to Exercise in ...