Background Cardiac MRI has been shown to be the gold standard for noninvasive assessment of myocardial fibrosis. The extent of fibrosis has been associated with worse outcomes in patients undergoing CABG surgery. The presence of fibrosis and associated clinical features of patients with chronic mitral regurgitation undergoing mitral valve repair have not been described. The objective of this st...

The objective of the present study was to assess the feasibility of working heart off-pump cardiac repair (OPCARE), for example, for simple congenital defects or valves, with the help of a commercially available surgical robot in order to identify problem areas and to explore potential solutions. OPCARE was studied in four bovine experiments using the Zeus (Computermotion, Santa Barbara, CA, US...

Soon after the development of "closed" techniques for the surgical repair of acquired cardiac valvular lesions, a postoperative syndrome characterized mainly by the development of fever and pleuropericarditis was recognized in many of the patients undergoing these procedures.' The advent of "open" cardiac surgical procedures employing cardiopulmonary bypass has resulted in the recent recognitio...

introduction: an attack of acute myocardial infarction (mi) poses the threat of great damage to cardiac tissue. operative therapeutic modalities such as coronary artery bypass grafting (cabg) may enhance myocardial perfusion in high-grade coronary vasculature occlusions. it has been shown previously that low-level laser therapy (lllt) significantly reduces infarct size following induction of my...

The recent article by Tang et al. [1] supports the idea that Nuss repair improves cardiopulmonary exercise function in teenagers with moderate-to-severe pectus excavatum (PEx). We would like to congratulate the authors for this study and emphasize the relevance of this research, as well as their results, by making some brief remarks. First, the authors circumvented the difficulties in measuring...

Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, includi...

As heart failure due to myocardial infarction remains a leading cause of morbidity worldwide, cell-based cardiac regenerative therapy using cardiac progenitor cells (CPCs) could provide a potential treatment for the repair of injured myocardium. As adult CPCs may have limitations regarding tissue accessibility and proliferative ability, CPCs derived from embryonic stem cells (ESCs) could serve ...

The effect of the potent antitumor antiobiotic Adriamycin (ADM) on DNA replication and unscheduled DNA synthesis in cultured rat cardiac cells was investigated. Autoradiography and [3H]thymidine incorporation studies were carried out on parallel cultures. DNA replication was depressed for up to 6 days following a 3-hr pulse of ADM administration. An ADM concentration of 1 microgram/ml which was...

objective(s): the aim of this study was to estimate effects of hyperbaric (hb) treatment by determination of cd15s and cd11b leukocyte proinflammatory markers expression.  in addition, this study describes changes in cd77 and cd34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. materials and methods:expression of cd11b and cd...

Cardiac surgery includes procedures performed on the pericardium, cardiac ventricles, atria, venae cavae, aorta, and main pulmonary artery. Closed cardiac procedures (i.e., those that do not require opening major cardiac structures) are most commonly performed; however, some conditions require open cardiac surgery (i.e., a major cardiac structure must be opened to accomplish the repair). Open c...