i b h e o w m i n V n S t o o h r p fi a A e t r A a a V he advances in cardiac electrophysiology during 2003 will e divided into three basic categories: mechanisms, genetics, nd therapy, the latter including ablation, devices, drugs, and unique pacing application in heart failure. This brief ummary is not a comprehensive review article, and cannot o justice to all the efforts and many publicat...

Tachycardias that are successfully ablated in the vicinity of the atrioventricular (AV) node are common, and although frequently successfully treated, are among the most difficult arrhythmias to understand in cardiac electrophysiology. Even AV node reentrant tachycardia (AVNRT), despite near universal cure, is complex with the anatomic constructs for typical, atypical forms, left-sided AVNRT, u...

This two-part manuscript reviews diagnostic pacing maneuvers for supraventricular tachycardia (SVT). Part one will involve a detailed consideration of ventricular overdrive pacing (VOP), since this pacing maneuver provides the diagnosis in the majority of cases. This will include a review of the post-VOP response, fusion during entrainment, the importance of the VOP site, quantitative results o...

Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems, the interactions between components are often difficult or impossible to understand without the help of mathematical models. Mathematical models of cardiac ...

One of the great discoveries in cardiac electrophysiology was the recognition of the crucial role of pulmonary vein (PV) myocardial sleeves for the initiation of atrial fibrillation (AF). Based on this concept, catheter ablation aiming at electrical isolation of all pulmonary veins has become the routine approach for of paroxysmal AF. Another concept implies selective isolation only of arrhythm...

In this paper, we deal with the problem of determining perfectly insulating regions (cavities) from one boundary measurement in a nonlinear elliptic equation arising cardiac electrophysiology. Based on results obtained [9] propose new reconstruction algorithm based Γ-convergence. The relevance and applicability approach are then shown through several numerical experiments.

BACKGROUND Voltage-sensitive dyes are important tools for mapping electrical activity in the heart. However, little is known about the effects of voltage-sensitive dyes on cardiac electrophysiology. OBJECTIVE To test the hypothesis that the voltage-sensitive dye di-4-ANEPPS modulates cardiac impulse propagation. METHODS Electrical and optical mapping experiments were performed in isolated L...

Recent progress in cardiac catheterization and devices has allowed the development of new therapies for severe cardiac diseases like arrhythmias and heart failure. The skills required for such interventions are very challenging to learn, and are typically acquired over several years. Virtual reality simulators may reduce this burden by allowing trainees to practice such procedures without risk ...

flecainide has been known to cause torsades de pointes (tdp) in patients with structural heart disease and its mechanism has been attributed to use-dependency. we present a patient with flecainide-induced tdp in the absence of any other precipitating factors.this case highlights potential reverse use dependence associated with flecainide resulting in tdp.

Basic cardiac electrophysiology is foundational to understanding normal cardiac function in terms of rate and rhythm and initiation of cardiac muscle contraction. The primary clinical tool for assessing cardiac electrical events is the electrocardiogram (ECG), which provides global and regional information on rate, rhythm, and electrical conduction as well as changes in electrical activity asso...