Introduction Since the pioneering work of Fabiato and Fabiato (1975), studies on myocardial function from analysis of single cardiac muscle cells have received an increased attention. Experiments conducted at the isolated cell level enable an analysis of cardiomyocyte response to mechanical stress, as well as a visualisation of fast cytosolic and nuclear calcium dynamics in contracting cardiac ...

The existence of an intracellular pool of fatty acid translocase (FAT/CD36), an 88-kDa membrane transporter for long-chain fatty acids (FAs), and the ability of insulin to induce translocation events prompted us to investigate the direct effects of insulin on cellular uptake of FA by the heart. Insulin (0.1 nmol/l and higher) increased FA uptake by isolated rat cardiac myocytes by 1.5-fold. Thi...

bstract-Cardiovascular response to running exercise was studied ith a simple pulsatile cardiovascular model. Published perimental data during graded exercise were used to tune the odel parameters. Study results show that cardiac output is odulated by rhythmic muscle contractions during running. It cillates when step rate and heart rate are not synchronised but abilises when they are synchronise...

In cardiac cells, Ca2+ signals appear as brief transients responsible for controlling both contraction and transcription. Information may be encoded in these digital signals through changes in both frequency and shape. An increase in Ca2+ signalling contributes to a process of phenotypic remodelling during hypertrophy. The increase in Ca2+ that drives the larger contractions may be responsible ...

We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A 3D continuum mathematical model is presented based on a hyperelastic description of the passive mechanical properties of the cell, combined with an active-strain framework to describe the active shortening of myocytes and its coupling with cytosolic and ...

Background The impulse-conducting system that coordinates the cardiac cycle requires a well-orchestrated interplay of its multiple heterogeneous components for synchronous and reliable contractions [1]. Thus, detailed insight into the anatomy of the conduction system would be of great significance to understand the cardiac performance arising from electro-mechanical activity [2,3]. To date, the...

We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A 3D continuum mathematical model is presented based on a hyperelastic description of the passive mechanical properties of the cell, combined with an active-strain framework to describe the active shortening of myocytes and its coupling with cytosolic and ...

In this paper we discuss on the fixed points of asymptotic contractions and Boyd-Wong type contractions in uniform spaces equipped with an E-distance. A new version ofKirk's fixed point theorem is given for asymptotic contractions and Boyd-Wong type contractions is investigated in uniform spaces.

propafenone hci (p), is a relatively new class ic antiarrhythmic agent. it has been reported to be superior to conventional antiarrhythmics in the control of supraventricular, ventricular and wpw associated tachyarrhythmias. it has been also shown to be well tolerated. in our study protocol, which extends over 2~ years period , we used (p) in 87 patients for management of various types of cardi...

ventricular arrhythmias are one of the most important causes of annual deaths in the world, which may lead to sudden cardiac deaths. accurate and early diagnosis of ventricular arrhythmias in heart diseases is essential for preventing mortality in cardiac patients. ventricular activity on the electrocardiogram (ecg) signal is in the interval from the beginning of qrs complex to t wave end. vari...