This report describes heart disease in a 32-year-old man with the syndrome of chronic progressive external ophthalmoplegia (CPEO). The surface electrocardiogram showed first degree AV block and left bundle-branch block and there was HV prolongation on the His bundle electrogram. Endomyocardial biopsy showed the changes of hypertrophy on light microscopy, and on electron microscopy there were in...

Many physical processes have distributions of times between events that have non-normalizable, power law probability density functions ~PDF’s!. The moments of such distributions are not defined. We found that the PDF’s of the times between events of ventricular tachyarrhythmia ~rapid heart rate! and premature ventricular contractions have a power law form indicative of a non-normalizable distri...

Cardiac Abnormalities in Subarachnoid Hemorrhage: A Resume • There have been numerous reports demonstrating electrocardiographical changes secondary to subarachnoid hemorrhage, consisting of atrial and ventricular arrhythmias, alterations in QRS configuration, Q-T interval prolongation, T-wave abnormalities, and S-T segment elevation or depression. Abnormalities of cardiac muscle and subendocar...

Background: Patients with chronic kidney disease (CKD) who undergo chronic haemodialysis (HD) show altered sympathetic tone, which is related to a higher cardiovascular mortality. The purpose of this study was to investigate the effect of transition from pre-HD to HD on cardiac sympathetic innervation. Methods: Eighteen patients aged 58 ± 18 years (mean ± standard deviation [SD]), 13 males and ...

RESPONSE BY: MASATO NISHIDE, M.D. To the Editor: The study reported by Nishide et al (Stroke 14,541-545, July-August 1983) is of interest in that atrial fibrillation and/or rheumatic heart disease (generally accepted as being associated with an increased risk of systemic thrombo-embolism) were found significantly more frequently in patients presenting with "ischemic cerebrovascular disease" tha...

Repolarization abnormalities, including those induced by the congenital or acquired long QT (LQT) syndrome, provide a substrate for life-threatening cardiac arrhythmias. In this article, we use computational biology to link HERG mutations mechanistically to the resulting abnormalities of the whole-cell action potential. We study how the kinetic properties of I(Ks) (the slow delayed rectifier) t...

Cardiac abnormalities were identified in patients with familial palmoplantar keratosis. All of them were descended from families on the Greek island of Naxos. Four families were studied and nine cases of palmoplantar keratosis were identified; seven of them showed symptoms and signs of heart disease. Cardiomegaly on chest x ray and electrocardiographic abnormalities were common findings. Three ...

Klippel-Feil syndrome is known by the classic triad of shortness of the neck , limitation of neck movements, and a low posterior hairline. There are often accompanying cervical spinal abnormalities such as kyphoscoliosis as well as urogenital and cardiac abnormalities. Presented here we have a 20 year old young man with hypoesthesia and decreased motor function in the right hand. The probl...

Background: Dilated Cardiomyopathy (DCM) is the second most important cause of heart failure in Tanzania, and associated with high mortality. Arrhythmias and/or conduction abnormalities contribute to sudden cardiac death, which occurs up 50% DCM patients. Data on burden factors rhythm patients may help prepare local treatment protocols.