Background—The magnitude of the association between Helicobacter pylori and incidence of gastric cancer is unclear. H pylori infection and the circulating antibody response can be lost with development of cancer; thus retrospective studies are subject to bias resulting from classification of cases as H pylori negative when they were infected in the past. Aims—To combine data from all case contr...

BACKGROUND Recent reports suggest that the incidences of cardia and gastroesophageal junction carcinomas have increased markedly. The influence of improvements in cancer site classification (i.e., from no specific site to a specific site) on these incidence rates is unknown. METHODS We analyzed data for all gastric cancers reported to the National Cancer Institute's Surveillance, Epidemiology...

BACKGROUND It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS The association between peptic ulcer and gastric cancer was studied among patients followed ...

Radionuclide oesophageal transit studies and manometry have been carried out in 15 patients with achalasia of the cardia, before treatment, after a course of nifedipine and after pneumatic bag dilatation. Transit studies were also done in 10 patients after cardiomyotomy and in 10 normal subjects. Images were recorded with the subjects seated in front of a gamma camera while swallowing a 10 ml b...

" Cardiospasm " is a rare condition of the oesophagus, giving rise to its dilatation and to projectile regurgitant vomiting in many cases, and to dysphagia as well, in a few. Synonyms.?There are numerous terms used for this condition?viz., cardiospasm, hiatal cesophagismus, functional hiatal stenosis, preventriculosis, phrenospasm, etc. The one most commonly used is " cardiospasm." But unfortun...

Analyses of cancer incidence data in the United States and Western Europe revealed steadily rising rates over the past decades of adenocarcinomas of the esophagus and gastric cardia. Genetic information on gastric cardia adenocarcinoma and its preneoplasias is sparse. We have used comparative genomic hybridization to obtain a genome-wide overview of 20 archival gastric cardia adenocarcinomas an...

Background Adenocarcinomas at the cardia are biologically aggressive tumors with poor long-term survival following curative resection. For resectable adenocarcinoma of the cardia, mostly esophagus extended total gastrectomy or esophagus extended proximal gastric resection is performed; however, the surgical approach, transhiatal or transthoracic, is still under discussion. Postoperative morbidi...

OBJECTIVES Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. METHODS We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 ma...